幼儿期结肠钠转运的发育及其受醛固酮的调节。
Development of colonic sodium transport in early childhood and its regulation by aldosterone.
作者信息
Jenkins H R, Fenton T R, McIntosh N, Dillon M J, Milla P J
机构信息
Institute of Child Health, London.
出版信息
Gut. 1990 Feb;31(2):194-7. doi: 10.1136/gut.31.2.194.
Abstract
Aldosterone is important in the regulation of sodium conservation by both kidney and colon. In the very preterm neonate marked urinary salt wasting occurs because of immature renal tubular function, but little is known of the ontogeny of colonic transport processes. Using an in vivo rectal dialysis technique, we have shown that in the human infant the colon has well developed salt conserving mechanisms from early in the last trimester of gestation and that aldosterone is an important regulatory hormone. Sodium transport mechanisms in the colon appear to develop before those in the kidney and it is possible that the colon is the major organ of sodium conservation in the preterm neonate.
摘要
醛固酮在肾脏和结肠对钠的保留调节中起着重要作用。由于肾小管功能不成熟，极早产儿会出现明显的尿盐丢失，但关于结肠转运过程的个体发生知之甚少。我们采用体内直肠透析技术，已证明在人类婴儿中，结肠从妊娠晚期早期就具有发育良好的盐保留机制，且醛固酮是一种重要的调节激素。结肠中的钠转运机制似乎比肾脏中的发育更早，结肠有可能是早产儿钠保留的主要器官。
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