胱胺对γ-谷氨酰半胱氨酸合成酶的抑制作用：一种治疗5-氧脯氨酸尿症（焦谷氨酸尿症）的方法。 - Suppr

Suppr

超能文献

Inhibition of gamma-glutamylcysteine synthetase by cystamine: an approach to a therapy of 5-oxoprolinuria (pyroglutamic aciduria).

作者信息

Griffith O W, Larsson A, Meister A

出版信息

Biochem Biophys Res Commun. 1977 Dec 7;79(3):919-25. doi: 10.1016/0006-291x(77)91198-6.

DOI:10.1016/0006-291x(77)91198-6

PMID:23121

Abstract

摘要

相似文献

Inhibition of gamma-glutamylcysteine synthetase by cystamine: an approach to a therapy of 5-oxoprolinuria (pyroglutamic aciduria).胱胺对γ-谷氨酰半胱氨酸合成酶的抑制作用：一种治疗5-氧脯氨酸尿症（焦谷氨酸尿症）的方法。

Biochem Biophys Res Commun. 1977 Dec 7;79(3):919-25. doi: 10.1016/0006-291x(77)91198-6.

Structural studies on the inactivation of gamma-glutamylcysteine synthetase by the disulphide analogues of radioprotective cysteamine derivatives. Effects of aminoalkyl and hydroxyalkyl chain length and beta beta-bis-dimethylation.辐射防护性半胱胺衍生物的二硫化物类似物对γ-谷氨酰半胱氨酸合成酶失活的结构研究。氨基烷基和羟烷基链长度以及β,β-双甲基化的影响。

Biochem J. 1990 Apr 15;267(2):291-6. doi: 10.1042/bj2670291.

Inactivation of gamma-glutamylcysteine synthetase, but not of glutamine synthetase, by S-sulfocysteine and S-sulfohomocysteine.S-磺基半胱氨酸和S-磺基高半胱氨酸使γ-谷氨酰半胱氨酸合成酶失活，但不使谷氨酰胺合成酶失活。

J Biol Chem. 1987 Dec 15;262(35):16771-7.

Gamma-glutamylcysteine synthetase. Interactions of an essential sulfhydryl group.γ-谷氨酰半胱氨酸合成酶。一个必需巯基的相互作用。

J Biol Chem. 1984 Mar 25;259(6):3534-8.

Inactivation of human gamma-glutamylcysteine synthetase by cystamine. Demonstration and quantification of enzyme-ligand complexes.胱胺对人γ-谷氨酰半胱氨酸合成酶的失活作用。酶-配体复合物的证明与定量分析。

J Biol Chem. 1978 Apr 25;253(8):2615-23.

Interaction of L- and D-3-amino-1-chloro-2-pentanone with gamma-glutamylcysteine synthetase.L-和D-3-氨基-1-氯-2-戊酮与γ-谷氨酰半胱氨酸合成酶的相互作用。

J Biol Chem. 1980 Dec 25;255(24):11732-6.

Cystamine-Sepharose. A probe for the active site of gamma-glutamylcysteine synthetase.胱胺-琼脂糖凝胶。γ-谷氨酰半胱氨酸合成酶活性位点的一种探针。

J Biol Chem. 1982 May 10;257(9):5092-6.

Selective inhibition of gamma-glutamyl-cycle enzymes by substrate analogs.底物类似物对γ-谷氨酰循环酶的选择性抑制作用。

Proc Natl Acad Sci U S A. 1977 Aug;74(8):3330-4. doi: 10.1073/pnas.74.8.3330.

Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.原硫氨酸亚砜亚胺（S-正丙基高半胱氨酸亚砜亚胺）对谷胱甘肽生物合成的抑制作用，γ-谷氨酰半胱氨酸合成酶的一种选择性抑制剂。

J Biol Chem. 1979 Feb 25;254(4):1205-10.

Interaction of phosphonates related to glutathione with the rat kidney gamma-glutamylcysteine synthetase.与谷胱甘肽相关的膦酸盐与大鼠肾脏γ-谷氨酰半胱氨酸合成酶的相互作用。

Biochimie. 1987 May;69(5):461-7. doi: 10.1016/0300-9084(87)90083-6.

引用本文的文献

Development of an Activity-Based Ratiometric Electrochemical Switch for Direct, Real-Time Sensing of Pantetheinase in Live Cells, Blood, and Urine Samples.基于活性的比率型电化学开关的开发，用于直接、实时检测活细胞、血液和尿液样本中的泛酰巯基乙胺酶。

ACS Sens. 2024 Oct 25;9(10):5436-5444. doi: 10.1021/acssensors.4c01658. Epub 2024 Sep 27.

Regulation of coenzyme A levels by degradation: the 'Ins and Outs'.辅酶 A 水平的降解调控：“内与外”。

Prog Lipid Res. 2020 Apr;78:101028. doi: 10.1016/j.plipres.2020.101028. Epub 2020 Mar 29.

Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of -acetyl-cysteine and β-mercaptoethylamine.使用联合用药方法增强 GSH：I-152，半胱氨酸和β-巯基乙胺的缀合物。

Nutrients. 2019 Jun 7;11(6):1291. doi: 10.3390/nu11061291.

VNN1 overexpression is associated with poor response to preoperative chemoradiotherapy and adverse prognosis in patients with rectal cancers.VNN1过表达与直肠癌患者术前放化疗反应不佳及不良预后相关。

Am J Transl Res. 2016 Oct 15;8(10):4455-4463. eCollection 2016.

Transglutaminase inhibition: A therapy to protect cells from death in neurodegeneration?转谷氨酰胺酶抑制：一种在神经退行性变中保护细胞免于死亡的疗法？

World J Biol Chem. 2012 Nov 26;3(11):184-6. doi: 10.4331/wjbc.v3.i11.184.

Physio-pathological roles of transglutaminase-catalyzed reactions.转谷氨酰胺酶催化反应的生理病理作用。

World J Biol Chem. 2010 May 26;1(5):181-7. doi: 10.4331/wjbc.v1.i5.181.

Possible role of the transglutaminases in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases.转谷氨酰胺酶在阿尔茨海默病及其他神经退行性疾病发病机制中的可能作用。

Int J Alzheimers Dis. 2011 Feb 16;2011:865432. doi: 10.4061/2011/865432.

Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium.半胱胺，泛酸酶的天然代谢产物，对疟原虫表现出特异性活性。

Exp Parasitol. 2010 Aug;125(4):315-24. doi: 10.1016/j.exppara.2010.02.009. Epub 2010 Feb 26.

Stimulation of h(2)s emission from pumpkin leaves by inhibition of glutathione synthesis.通过抑制谷胱甘肽合成刺激南瓜叶片中h(2)s的释放

Plant Physiol. 1982 Apr;69(4):766-70. doi: 10.1104/pp.69.4.766.

Vanin-1-/- mice exhibit a glutathione-mediated tissue resistance to oxidative stress.Vanin-1基因敲除小鼠表现出谷胱甘肽介导的组织对氧化应激的抗性。

Mol Cell Biol. 2004 Aug;24(16):7214-24. doi: 10.1128/MCB.24.16.7214-7224.2004.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验