原硫氨酸亚砜亚胺（S-正丙基高半胱氨酸亚砜亚胺）对谷胱甘肽生物合成的抑制作用，γ-谷氨酰半胱氨酸合成酶的一种选择性抑制剂。 - Suppr

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超能文献

Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.

作者信息

Griffith O W, Anderson M E, Meister A

出版信息

J Biol Chem. 1979 Feb 25;254(4):1205-10.

PMID:33187

Abstract

摘要

相似文献

Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.原硫氨酸亚砜亚胺（S-正丙基高半胱氨酸亚砜亚胺）对谷胱甘肽生物合成的抑制作用，γ-谷氨酰半胱氨酸合成酶的一种选择性抑制剂。

J Biol Chem. 1979 Feb 25;254(4):1205-10.

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).丁硫氨酸亚砜胺（S-正丁基高半胱氨酸亚砜胺）对谷胱甘肽合成的强效特异性抑制作用。

J Biol Chem. 1979 Aug 25;254(16):7558-60.

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.丁硫氨酸亚砜胺及其高级同系物（谷胱甘肽合成的强效抑制剂）的作用机制、代谢及毒性

J Biol Chem. 1982 Nov 25;257(22):13704-12.

Differential inhibition of glutamine and gamma-glutamylcysteine synthetases by alpha-alkyl analogs of methionine sulfoximine that induce convulsions.可诱发惊厥的蛋氨酸亚砜亚胺α-烷基类似物对谷氨酰胺和γ-谷氨酰半胱氨酸合成酶的差异性抑制作用。

J Biol Chem. 1978 Apr 10;253(7):2333-8.

Effects of methionine sulfoximine analogs on the synthesis of glutamine and glutathione: possible chemotherapeutic implications.蛋氨酸亚砜亚胺类似物对谷氨酰胺和谷胱甘肽合成的影响：可能的化疗意义。

Cancer Treat Rep. 1979 Jun;63(6):1115-21.

Buthionine sulfoximine inhibition of glutathione biosynthesis enhances hepatic lipid peroxidation in rats during acute ethanol intoxication.丁硫氨酸亚砜亚胺对谷胱甘肽生物合成的抑制作用会增强急性乙醇中毒大鼠的肝脏脂质过氧化。

Alcohol Alcohol. 1989;24(6):519-24. doi: 10.1093/oxfordjournals.alcalc.a044954.

Inhibition of gamma-glutamylcysteine synthetase by L-methionine-S-sulfoximine.L-蛋氨酸-S-亚砜亚胺对γ-谷氨酰半胱氨酸合成酶的抑制作用。

J Biol Chem. 1973 Oct 10;248(19):6684-90.

On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulation.γ-谷氨酰半胱氨酸合成酶活性位点硫醇：与催化、抑制和调节的关系

Proc Natl Acad Sci U S A. 1988 Apr;85(8):2464-8. doi: 10.1073/pnas.85.8.2464.

Glutathione biosynthesis and its inhibition.谷胱甘肽的生物合成及其抑制作用。

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Depletion of glutathione by inhibition of biosynthesis.通过抑制生物合成消耗谷胱甘肽。

Methods Enzymol. 1981;77:59-63. doi: 10.1016/s0076-6879(81)77011-3.

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