Toll 样受体 10-1-6 基因簇多态性与韩国人群良性前列腺增生无关。
Toll-like receptor 10-1-6 gene cluster polymorphisms are not associated with benign prostatic hyperplasia in korean population.
机构信息
Department of Pharmacology, Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea.
Development of Ginseng and Medical Plants Research Institute, Rural Administration, Eumseong, Korea.
出版信息
Int Neurourol J. 2014 Mar;18(1):10-5. doi: 10.5213/inj.2014.18.1.10. Epub 2014 Mar 31.
PURPOSE
Inflammation and infection have been associated with the pathogenesis of benign prostatic hyperplasia (BPH). Toll-like receptors (TLRs) play key roles in the innate immune system and initiate the inflammatory response to foreign pathogens. We investigated the relationship between TLR10-1-6 gene cluster polymorphisms and BPH.
METHODS
We genotyped four promoter single nucleotide polymorphisms (SNPs) (TLR10, rs10004195; TLR1, rs5743557; and TLR6, rs1039560 and rs1039559) by directly sequencing (233 BPH patients and 214 control subjects). SNPStats and Haploview version 4.02 were used to analyze the data. Multiple logistic regression models (log-additive, dominant, and recessive) were performed to determine odds ratios (ORs), 95% confidence intervals (CIs), and P-values.
RESULTS
The genotype and allele frequencies of each SNP was not different between the BPH and control groups (P>0.05). Haplotype analysis showed no association between the haplotype in the linkage disequilibrium (LD) block and BPH (P>0.05), although the LD block was constructed.
CONCLUSIONS
These results indicate that the TLR10-1-6 gene cluster may be not associated with the development of BPH in the Korean population.
目的
炎症和感染与良性前列腺增生（BPH）的发病机制有关。Toll 样受体（TLR）在先天免疫系统中发挥关键作用，并引发对外来病原体的炎症反应。我们研究了 TLR10-1-6 基因簇多态性与 BPH 之间的关系。
方法
我们通过直接测序（233 例 BPH 患者和 214 例对照）对四个启动子单核苷酸多态性（SNP）（TLR10、rs10004195；TLR1、rs5743557；和 TLR6、rs1039560 和 rs1039559）进行基因分型。使用 SNPStats 和 Haploview 版本 4.02 分析数据。采用多元逻辑回归模型（加性、显性和隐性）确定比值比（OR）、95%置信区间（CI）和 P 值。
结果
每个 SNP 的基因型和等位基因频率在 BPH 和对照组之间没有差异（P>0.05）。连锁不平衡（LD）块中的单体型分析表明，单体型与 BPH 之间没有关联（P>0.05），尽管构建了 LD 块。
结论
这些结果表明，TLR10-1-6 基因簇可能与韩国人群中 BPH 的发生无关。
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