基因多态性 rs3027898 与仅局限于甲状腺的甲状腺乳头状癌的相关性：一项初步研究。
Association of Gene Polymorphism rs3027898 With Papillary Cancer Restricted to the Thyroid Gland: A Pilot Study.
机构信息
Laboratory of Medical Biology - Genetics, Faculty of Medicine, School of Health Sciences, Aristotle University, Thessaloniki, Greece
First Propedeutic Department of Surgery, AHEPA University Hospital, Faculty of Medicine, School of Health Sciences, Aristotle University, Thessaloniki, Greece.
出版信息
In Vivo. 2019 Nov-Dec;33(6):2281-2285. doi: 10.21873/invivo.11734.
BACKGROUND/AIM: The incidence of thyroid cancer has increased predominantly due to an increase in papillary thyroid cancer (PTC). Alteration of toll-like receptor function has been reported to play a crucial role in carcinogenesis. The aim of the present study was to investigate predisposition to PTC associated with genetic markers of toll-like receptor and interleukin-1 receptor pathways involving nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-ĸB) stimulation. Specifically, the study focused on the following genes: interleukin-1 receptor-associated kinase 1 (IRAK1, rs3027898), NF-ĸB inhibitor alpha (NFKBIA, rs696), NF-ĸB subunit 1 (NFKB1, rs28362491), and microRNA-146a (miR-146a, rs2910164).
PATIENTS AND METHODS
Forty-eight unrelated patients with papillary cancer restricted to the thyroid gland and 93 healthy volunteers were enrolled in the study.
RESULTS
A strong statistically significant difference was observed between patients with PTC and controls for IRAK1 rs3027898 variant. When the statistical analysis was replicated taking into account patient's sex, the rs3027898 A allele was revealed to be the risky variant in males.
CONCLUSION
Additional studies in larger groups of patients of various origins are needed to validate these preliminary findings.
背景/目的：甲状腺癌的发病率主要因乳头状甲状腺癌（PTC）的增加而上升。据报道， toll 样受体功能的改变在致癌作用中起着至关重要的作用。本研究旨在探讨与核因子 kappa-轻链增强子活化 B 细胞（NF-κB）刺激相关的 toll 样受体和白细胞介素-1 受体途径的遗传标记物相关的 PTC 易感性。具体来说，该研究集中在以下基因：白细胞介素-1 受体相关激酶 1（IRAK1，rs3027898）、NF-κB 抑制剂α（NFKBIA，rs696）、NF-κB 亚基 1（NFKB1，rs28362491）和 microRNA-146a（miR-146a，rs2910164）。
患者和方法
本研究纳入了 48 例局限于甲状腺的乳头状癌患者和 93 名健康志愿者。
结果
在 PTC 患者和对照组之间，IRAK1 rs3027898 变体存在强烈的统计学显著差异。当考虑患者性别进行统计学分析时，rs3027898 A 等位基因被揭示为男性的风险变异体。
结论
需要在不同来源的更大患者群体中进行进一步的研究，以验证这些初步发现。
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