肝素的抗凝作用可通过鱼精蛋白选择渗透膜进行可逆检测。
Reversible sensing of the anticoagulant heparin with protamine permselective membranes.
机构信息
Department of Inorganic, Analytical and Applied Chemistry, University of Geneva, Quai E. Ansermet 30, 1211 Geneva, Switzerland.
出版信息
Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12575-8. doi: 10.1002/anie.201207444. Epub 2012 Nov 4.
PMID:23124959
Abstract
A permselective membrane electrode allows the rapid and operationally reversible detection of the polycationic polypeptide protamine in physiological samples. Anticoagulant levels of heparin can be measured in undiluted whole blood by adding a known excess of its antidote protamine to discrete blood samples.
摘要
一种选择渗透性膜电极允许在生理样品中快速且可操作性地可逆地检测聚阳离子多肽鱼精蛋白。通过向离散的血样中加入过量已知的其解毒剂鱼精蛋白，可以在未稀释的全血中测量抗凝剂肝素的水平。
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