Toshkov I, Kirev T
Institute of General and Comparative Pathology, Bulgarian Academy of Sciences, Sofia.
J Cancer Res Clin Oncol. 1990;116(1):38-44. doi: 10.1007/BF01612638.
The type of mucoproteins in virus-induced duodenal adenomas in guinea fowl were compared with those in the normal duodenal mucosa. The mucin-producing cells in the latter contained a mixture of acid and neutral mucins. Neutral and sulphomucins prevailed in the crypts and in the lower part of the villi, while the amount of the sialomucins increased progressively toward the tip of the villi. In the adenomas, goblet cells were more numerous and were unevenly distributed. In their mucin profile the deeply located tumor glandular structures resembled normal crypts and lower parts of the villi and superficial portions of the adenomas were similar to the upper part of the villi. Qualitative changes in the mucin secretion with deviation from the normal vertical distribution of mucin types were rarely observed. The histochemical study carried out supplemented the histological characterization of the virus-induced duodenal adenomas and contributed to the elucidation of some aspects of their histogenesis.
将珍珠鸡病毒诱导的十二指肠腺瘤中的粘蛋白类型与正常十二指肠黏膜中的粘蛋白类型进行了比较。后者的粘蛋白分泌细胞含有酸性和中性粘蛋白的混合物。中性和硫粘蛋白在隐窝和绒毛下部占优势，而唾液酸粘蛋白的量则朝着绒毛尖端逐渐增加。在腺瘤中，杯状细胞数量更多且分布不均。在其粘蛋白谱中，位于深部的肿瘤腺结构类似于正常隐窝和绒毛下部，而腺瘤的浅表部分类似于绒毛上部。很少观察到粘蛋白分泌的定性变化以及与正常粘蛋白类型垂直分布的偏差。所进行的组织化学研究补充了病毒诱导的十二指肠腺瘤的组织学特征，并有助于阐明其组织发生的某些方面。
