Kirev T T, Toshkov I A, Mladenov Z M
Institute of General and Comparative Pathology, Bulgarian Academy of Sciences, Sofia.
J Natl Cancer Inst. 1987 Nov;79(5):1117-21.
Polypous growths of the duodenal mucosa were induced in guinea fowls after iv inoculation o virus strain Pts-56. The growths developed in about 60% of the experimental birds after a latent period of 4-6 months. The chronologic study of the alterations in the duodenal mucosa revealed consecutive occurrence of focal lymphoid cell infiltrations of the propria, restricted crypt hyperplasia, and enlargement of the villi followed by the formation of tubulovillous and tubulous adenomas. The virus-induced neoplasia of the guinea fowl duodenal mucosa morphologically closely resembled small intestinal adenomas in humans. Their formal genesis was similar to that of experimental intestinal tumors induced by chemical carcinogens.
给珍珠鸡静脉注射病毒株Pts - 56后，诱发了十二指肠黏膜的息肉样生长。在4至6个月的潜伏期后，约60%的实验鸡出现了这种生长。对十二指肠黏膜变化的时间顺序研究显示，固有层出现局灶性淋巴细胞浸润、局限性隐窝增生、绒毛增大，随后形成管状绒毛状和管状腺瘤。病毒诱导的珍珠鸡十二指肠黏膜肿瘤在形态上与人类小肠腺瘤极为相似。它们的形成机制与化学致癌物诱导的实验性肠道肿瘤相似。
