Sanchez-Sousa A, Torres C, Campello M G, Garcia C, Parras F, Cercenado E, Baquero F
Servicio de Microbiología, Hospital Ramón y Cajal, Madrid, Spain.
J Clin Pathol. 1990 Jan;43(1):79-81. doi: 10.1136/jcp.43.1.79.
The presence of antibodies was determined in the serum and cerebrospinal fluid in six patients with neurobrucellosis using the Rose Bengal test, the microdilution agglutination test, and the Coombs' test. Four of the patients were followed up for more than three months. The Rose Bengal test and the microagglutination test were positive in cerebrospinal fluid in five of the six cases at some stage. The Coombs' test was positive in cerebrospinal fluid in every patient and in one was the only positive serological test. Cerebrospinal fluid positivity is not excluded by low titres or negative results of antibodies in the serum for any of the three methods. A Coombs' test or some equivalent must always be made on the cerebrospinal fluid to diagnose neurobrucellosis.
采用玫瑰红试验、微量稀释凝集试验和库姆斯试验，对6例神经型布鲁氏菌病患者的血清和脑脊液中的抗体进行了检测。其中4例患者进行了超过3个月的随访。在6例患者中的5例的脑脊液中，玫瑰红试验和微量凝集试验在某些阶段呈阳性。库姆斯试验在每位患者的脑脊液中均呈阳性，且在1例患者中是唯一呈阳性的血清学检测。对于这三种方法中的任何一种，血清中抗体滴度低或结果为阴性都不能排除脑脊液呈阳性。为诊断神经型布鲁氏菌病，必须始终对脑脊液进行库姆斯试验或某种等效试验。
