Department of Chemical and Biological Engineering, University of Ottawa, 161 Louis-Pasteur, Ottawa, Canada K1N 6N5.
J Mech Behav Biomed Mater. 2013 Jan;17:333-6. doi: 10.1016/j.jmbbm.2012.07.007. Epub 2012 Aug 2.
Biocompatible polymers are commonly used to fabricate microfluidic channels for the study of biological flows such as blood microflows. The most common of these materials is polydimethylsiloxane (PDMS) which is very hydrophobic. Oxygenated plasma is advocated to treat the PDMS with reported decreases in contact angle i.e. increase the hydrophilicity of the material in order to make the liquid flow easily. All contact angle studies have been reported with water. Here the contact angles of blood suspensions, in saline and native plasma, are compared to each other and water on common microfluidic chip materials. The hydrophilic effect of plasma-treatment on PDMS is not found to be as significant with blood suspensions as it is with water. Red blood cells suspended in native plasma are found to have a greater contact angle than those suspended in saline.
生物相容性聚合物常用于制造微流道，以研究生物流动，如血液微流动。这些材料中最常见的是聚二甲基硅氧烷（PDMS），它的疏水性很强。含氧等离子体被提倡用来处理 PDMS，据报道，接触角会减小，即增加材料的亲水性，以便使液体更容易流动。所有的接触角研究都是用水来报告的。在这里，将血液悬浮液（在盐水中和天然血浆中）的接触角相互比较，并与常见的微流控芯片材料上的水进行比较。结果发现，与水相比，等离子体处理对 PDMS 的亲水效果在血液悬浮液中并不那么显著。与悬浮在盐水中的红细胞相比，悬浮在天然血浆中的红细胞的接触角更大。
