在巴布亚新几内亚戈罗卡地区对 A 组轮状病毒进行监测和分子特征分析。
Surveillance and molecular characterization of group A rotaviruses in Goroka, Papua New Guinea.
机构信息
Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
出版信息
Am J Trop Med Hyg. 2012 Dec;87(6):1145-8. doi: 10.4269/ajtmh.2012.12-0234. Epub 2012 Nov 5.
In this study, we investigated the molecular epidemiology of group A rotaviruses in cases of acute gastroenteritis in Goroka, Papua New Guinea. From April 2008 through November 2010, 813 diarrheal stool samples were collected from children < 5 years of age hospitalized with acute gastroenteritis. Rotavirus antigen was detected in 31.2% of samples using a commercial enzyme-linked immunosorbent assay. Genotyping revealed the presence of the globally circulating strains G1P[8] (50.0%), G3P[8] (23.0%), and G2P[4] (8.2%). The globally emerging strains G9 and G12 were detected in 1.2% and 6.1% of samples, respectively. Mixed infections were detected in a high proportion of samples (11.9%), with 9.0% and 3.7% of samples displaying multiple G and P genotypes, respectively.
在这项研究中，我们调查了巴布亚新几内亚戈罗卡地区急性肠胃炎病例中 A 组轮状病毒的分子流行病学情况。2008 年 4 月至 2010 年 11 月，采集了 813 名 5 岁以下因急性肠胃炎住院的儿童的腹泻粪便样本。使用商业酶联免疫吸附试验检测到 31.2%的样本中存在轮状病毒抗原。基因分型显示存在全球流行株 G1P[8]（50.0%）、G3P[8]（23.0%）和 G2P[4]（8.2%）。全球新兴株 G9 和 G12 的检出率分别为 1.2%和 6.1%。高比例的样本中检测到混合感染（11.9%），分别有 9.0%和 3.7%的样本显示多种 G 和 P 基因型。
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