Laboratory of Clinical & Epidemiological Virology, Department of Microbiology & Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, 3000, Leuven, Belgium.
Arch Virol. 2011 Aug;156(8):1397-413. doi: 10.1007/s00705-011-1006-z. Epub 2011 May 20.
In April 2008, a nucleotide-sequence-based, complete genome classification system was developed for group A rotaviruses (RVs). This system assigns a specific genotype to each of the 11 genome segments of a particular RV strain according to established nucleotide percent cutoff values. Using this approach, the genome of individual RV strains are given the complete descriptor of Gx-P[x]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx. The Rotavirus Classification Working Group (RCWG) was formed by scientists in the field to maintain, evaluate and develop the RV genotype classification system, in particular to aid in the designation of new genotypes. Since its conception, the group has ratified 51 new genotypes: as of April 2011, new genotypes for VP7 (G20-G27), VP4 (P[28]-P[35]), VP6 (I12-I16), VP1 (R5-R9), VP2 (C6-C9), VP3 (M7-M8), NSP1 (A15-A16), NSP2 (N6-N9), NSP3 (T8-T12), NSP4 (E12-E14) and NSP5/6 (H7-H11) have been defined for RV strains recovered from humans, cows, pigs, horses, mice, South American camelids (guanaco), chickens, turkeys, pheasants, bats and a sugar glider. With increasing numbers of complete RV genome sequences becoming available, a standardized RV strain nomenclature system is needed, and the RCWG proposes that individual RV strains are named as follows: RV group/species of origin/country of identification/common name/year of identification/G- and P-type. In collaboration with the National Center for Biotechnology Information (NCBI), the RCWG is also working on developing a RV-specific resource for the deposition of nucleotide sequences. This resource will provide useful information regarding RV strains, including, but not limited to, the individual gene genotypes and epidemiological and clinical information. Together, the proposed nomenclature system and the NCBI RV resource will offer highly useful tools for investigators to search for, retrieve, and analyze the ever-growing volume of RV genomic data.
在 2008 年 4 月，建立了基于核苷酸序列的 A 组轮状病毒（RV）完整基因组分类系统。该系统根据既定的核苷酸百分比截断值，为特定 RV 株的 11 个基因组片段中的每一个分配特定的基因型。使用这种方法，将个体 RV 株的基因组完整描述为 Gx-P[x]-Ix-Rx-Cx-Mx-Ax-Nx-Tx-Ex-Hx。轮状病毒分类工作组（RCWG）由该领域的科学家组成，旨在维护、评估和发展 RV 基因型分类系统，特别是为了帮助指定新的基因型。自成立以来，该小组已批准了 51 种新的基因型：截至 2011 年 4 月，已为 VP7（G20-G27）、VP4（P[28]-P[35]）、VP6（I12-I16）、VP1（R5-R9）、VP2（C6-C9）、VP3（M7-M8）、NSP1（A15-A16）、NSP2（N6-N9）、NSP3（T8-T12）、NSP4（E12-E14）和 NSP5/6（H7-H11）定义了新的 RV 基因型，这些基因型用于从人类、牛、猪、马、鼠、南美驼马（羊驼）、鸡、火鸡、鹧鸪、蝙蝠和蜜袋鼯中回收的 RV 株。随着越来越多的完整 RV 基因组序列可用，需要建立标准化的 RV 株命名系统，RCWG 建议个体 RV 株命名如下：RV 组/种属/鉴定国家/通用名/鉴定年份/G 型和 P 型。RCWG 与国家生物技术信息中心（NCBI）合作，正在开发用于核苷酸序列存储的 RV 专用资源。该资源将提供有关 RV 株的有用信息，包括但不限于各基因基因型以及流行病学和临床信息。命名系统和 NCBI RV 资源将为研究人员提供高度有用的工具，用于搜索、检索和分析不断增长的 RV 基因组数据量。
