Department of Mechanical Engineering, Michigan State University, East Lansing, Michigan 48824, USA.
J Biomed Mater Res A. 2013 May;101(5):1525-9. doi: 10.1002/jbm.a.34445. Epub 2012 Nov 5.
Understanding the mechanical behavior of the arterial wall and its spatial variations is essential for the study of vascular physiopathology and the design of biomedical devices that interact with the arterial wall. Although it is generally accepted that the aortic wall gets stiffer along its length, the spatial variations in the mechanical behavior of the thoracic aorta are not well understood. In this study, therefore, we investigate both longitudinal and circumferential variations in the mechanical properties of the porcine descending thoracic aorta. Using a previously developed experimental method and stress-strain analysis, the stress, stretch, tangent modulus (TM), and pressure-strain elastic modulus (PSEM) are estimated in the range of in vivo pressure. The results show that the longitudinal differences of both TM and PSEM are statistically significant in the posterior region but not in the anterior region. Both moduli are greater in the posterior distal region when compared with the other test regions. The findings of this study meet a need for clarifying the region investigated, especially in circumferential region, to study the regional variations in biomechanics of blood vessels.
了解动脉壁的力学行为及其空间变化对于研究血管生理病理学以及设计与动脉壁相互作用的生物医学设备至关重要。尽管人们普遍认为主动脉壁在其长度方向上会变得更硬，但胸主动脉力学行为的空间变化尚不清楚。因此，在这项研究中，我们研究了猪降主动脉的力学性能的纵向和周向变化。使用先前开发的实验方法和应力-应变分析，在体内压力范围内估计了应力、拉伸、切线模量 (TM) 和压力-应变弹性模量 (PSEM)。结果表明，TM 和 PSEM 的纵向差异在后区具有统计学意义，但在前区则没有。与其他测试区域相比，后远区的两个模量都更大。本研究的结果满足了澄清研究区域的需求，特别是在周向区域，以研究血管生物力学的区域变化。
