小鼠实验性自身免疫性前列腺炎（EAP）的菌株特异性诱导。
Strain-specific induction of experimental autoimmune prostatitis (EAP) in mice.
机构信息
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Prostate. 2013 May;73(6):651-6. doi: 10.1002/pros.22606. Epub 2012 Nov 5.
Abstract
BACKGROUND
Prostatitis, a clinical syndrome characterized by pelvic pain and inflammation, is common in adult males. Although several induced and spontaneous murine models of prostatitis have been explored, the role of genetic background on induction has not been well-defined.
METHODS
Using a standard methodology for the induction of experimental autoimmune prostatitis (EAP), we investigated both acute and chronic inflammation on several murine genetic backgrounds.
RESULTS
In our colony, nonobese diabetic (NOD) mice evinced spontaneous prostatitis that was not augmented by immunization with rat prostate extract (RPE). In contrast, the standard laboratory strain Balb/c developed chronic inflammation in response to RPE immunization. Development of EAP in other strains was variable.
CONCLUSIONS
These data suggest that Balb/c mice injected with RPE may provide a useful model for chronic prostatic inflammation.
摘要
背景
前列腺炎是一种以骨盆疼痛和炎症为特征的临床综合征，常见于成年男性。尽管已经探索了几种诱导和自发的前列腺炎小鼠模型，但遗传背景对诱导的作用尚未得到很好的定义。
方法
我们使用标准的实验性自身免疫性前列腺炎（EAP）诱导方法，在几种不同的小鼠遗传背景下研究了急性和慢性炎症。
结果
在我们的实验中，非肥胖型糖尿病（NOD）小鼠出现了自发性前列腺炎，而用大鼠前列腺提取物（RPE）免疫则不会加剧这种炎症。相比之下，标准实验室品系 Balb/c 对 RPE 免疫反应产生慢性炎症。其他品系的 EAP 发展情况则有所不同。
结论
这些数据表明，用 RPE 注射的 Balb/c 小鼠可能为慢性前列腺炎症提供了一个有用的模型。
相似文献
1
Strain-specific induction of experimental autoimmune prostatitis (EAP) in mice.小鼠实验性自身免疫性前列腺炎（EAP）的菌株特异性诱导。
Prostate. 2013 May;73(6):651-6. doi: 10.1002/pros.22606. Epub 2012 Nov 5.
2
Chronic Pelvic Pain Development and Prostate Inflammation in Strains of Mice With Different Susceptibility to Experimental Autoimmune Prostatitis.不同易感性实验性自身免疫性前列腺炎小鼠品系中的慢性盆腔疼痛发展与前列腺炎症
Prostate. 2017 Jan;77(1):94-104. doi: 10.1002/pros.23252. Epub 2016 Oct 4.
3
Effect of alcohol on chronic pelvic pain and prostatic inflammation in a mouse model of experimental autoimmune prostatitis.酒精对实验性自身免疫性前列腺炎小鼠模型中慢性盆腔疼痛和前列腺炎症的影响。
Prostate. 2019 Sep;79(12):1439-1449. doi: 10.1002/pros.23866. Epub 2019 Jun 24.
4
IL17 Mediates Pelvic Pain in Experimental Autoimmune Prostatitis (EAP).白细胞介素17介导实验性自身免疫性前列腺炎（EAP）中的盆腔疼痛。
PLoS One. 2015 May 1;10(5):e0125623. doi: 10.1371/journal.pone.0125623. eCollection 2015.
5
Expression of CXCR3 on specific T cells is essential for homing to the prostate gland in an experimental model of chronic prostatitis/chronic pelvic pain syndrome.在慢性前列腺炎/慢性骨盆疼痛综合征的实验模型中，CXCR3 在特定 T 细胞上的表达对于归巢到前列腺是必需的。
J Immunol. 2013 Apr 1;190(7):3121-33. doi: 10.4049/jimmunol.1202482. Epub 2013 Mar 1.
6
Spontaneous and prostatic steroid binding protein peptide-induced autoimmune prostatitis in the nonobese diabetic mouse.非肥胖型糖尿病小鼠中自发性及前列腺类固醇结合蛋白肽诱导的自身免疫性前列腺炎
J Immunol. 2007 Aug 1;179(3):1559-67. doi: 10.4049/jimmunol.179.3.1559.
7
Non-obese diabetic (NOD) mice are genetically susceptible to experimental autoimmune prostatitis (EAP).非肥胖型糖尿病（NOD）小鼠对实验性自身免疫性前列腺炎（EAP）具有遗传易感性。
J Autoimmun. 1998 Dec;11(6):603-10. doi: 10.1006/jaut.1998.0248.
8
Prostatein or steroid binding protein (PSBP) induces experimental autoimmune prostatitis (EAP) in NOD mice.前列腺素或类固醇结合蛋白（PSBP）可诱导非肥胖糖尿病（NOD）小鼠发生实验性自身免疫性前列腺炎（EAP）。
Clin Immunol. 2002 Nov;105(2):176-84. doi: 10.1006/clim.2002.5281.
9
Regulatory T cells control strain specific resistance to Experimental Autoimmune Prostatitis.调节性 T 细胞控制实验性自身免疫性前列腺炎的菌株特异性抗性。
Sci Rep. 2016 Sep 14;6:33097. doi: 10.1038/srep33097.
10
CD8 T cells are dispensable for experimental autoimmune prostatitis induction and chronic pelvic pain development.CD8 T 细胞对于实验性自身免疫性前列腺炎的诱导和慢性盆腔疼痛的发展是可有可无的。
Front Immunol. 2024 May 14;15:1387142. doi: 10.3389/fimmu.2024.1387142. eCollection 2024.
引用本文的文献
1
Trends in experimental autoimmune prostatitis: insights into pathogenesis, therapeutic strategies, and redefinition.实验性自身免疫性前列腺炎的研究趋势：对发病机制、治疗策略及重新定义的见解
Am J Clin Exp Urol. 2024 Apr 15;12(2):52-63. doi: 10.62347/OUJJ3710. eCollection 2024.
2
Preclinical models and evaluation criteria of prostatitis.前列腺炎的临床前模型和评价标准。
Front Immunol. 2023 May 9;14:1183895. doi: 10.3389/fimmu.2023.1183895. eCollection 2023.
3
Applications of Vertebrate Models in Studying Prostatitis and Inflammation-Associated Prostatic Diseases.脊椎动物模型在前列腺炎及炎症相关前列腺疾病研究中的应用
Front Mol Biosci. 2022 Jul 5;9:898871. doi: 10.3389/fmolb.2022.898871. eCollection 2022.
4
Chronic oral exposure to glycated whey proteins increases survival of aged male NOD mice with autoimmune prostatitis by regulating the gut microbiome and anti-inflammatory responses.慢性口服糖化乳清蛋白通过调节肠道微生物组和抗炎反应增加了患有自身免疫性前列腺炎的老年雄性 NOD 小鼠的存活率。
Food Funct. 2020 Jan 29;11(1):153-162. doi: 10.1039/c9fo01740b.
5
Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse.高血糖症和 T 细胞浸润与非肥胖型糖尿病小鼠的基质和上皮前列腺增生有关。
Prostate. 2019 Jun;79(9):980-993. doi: 10.1002/pros.23809. Epub 2019 Apr 18.
6
Genetic and Environmental Influences on Urinary Conditions in Men: A Classical Twin Study.遗传和环境因素对男性尿路状况的影响：一项经典的双胞胎研究。
Urology. 2019 Jul;129:54-59. doi: 10.1016/j.urology.2019.04.005. Epub 2019 Apr 13.
7
The Anti-Inflammatory Effects of a Yin Zhi Huang Soup in an Experimental Autoimmune Prostatitis Rat Model.茵栀黄汤对实验性自身免疫性前列腺炎大鼠模型的抗炎作用
Evid Based Complement Alternat Med. 2017;2017:7312938. doi: 10.1155/2017/7312938. Epub 2017 Dec 21.
8
Antagonists of growth hormone-releasing hormone inhibit proliferation induced by inflammation in prostatic epithelial cells.生长激素释放激素拮抗剂可抑制前列腺上皮细胞中炎症诱导的增殖。
Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1359-1364. doi: 10.1073/pnas.1620884114. Epub 2017 Jan 25.
9
Histopathological classification criteria of rat model of chronic prostatitis/chronic pelvic pain syndrome.大鼠慢性前列腺炎/慢性盆腔疼痛综合征模型的组织病理学分类标准
Int Urol Nephrol. 2015 Feb;47(2):307-16. doi: 10.1007/s11255-014-0868-x. Epub 2014 Nov 20.
10
Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment.间质干细胞作为炎症性前列腺微环境的载体。
Endocr Relat Cancer. 2013 Aug 23;20(5):R269-90. doi: 10.1530/ERC-13-0151. Print 2013 Oct.
本文引用的文献
1
Prostate autoimmunity: from experimental models to clinical counterparts.前列腺自身免疫：从实验模型到临床对应物。
Expert Rev Clin Immunol. 2009 Sep;5(5):577-86. doi: 10.1586/eci.09.37.
2
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators.解决炎症：双重抗炎和促消退脂质介质
Nat Rev Immunol. 2008 May;8(5):349-61. doi: 10.1038/nri2294.
3
Inflammation and benign prostatic hyperplasia.炎症与良性前列腺增生
Urol Clin North Am. 2008 Feb;35(1):109-15; vii. doi: 10.1016/j.ucl.2007.09.012.
4
Spontaneous and prostatic steroid binding protein peptide-induced autoimmune prostatitis in the nonobese diabetic mouse.非肥胖型糖尿病小鼠中自发性及前列腺类固醇结合蛋白肽诱导的自身免疫性前列腺炎
J Immunol. 2007 Aug 1;179(3):1559-67. doi: 10.4049/jimmunol.179.3.1559.
5
Autoimmune prostatitis: state of the art.自身免疫性前列腺炎：最新进展
Scand J Immunol. 2007 Aug-Sep;66(2-3):217-27. doi: 10.1111/j.1365-3083.2007.01971.x.
6
Role of bacteria in chronic prostatitis/chronic pelvic pain syndrome.细菌在慢性前列腺炎/慢性盆腔疼痛综合征中的作用。
Curr Urol Rep. 2005 Jul;6(4):300-6. doi: 10.1007/s11934-005-0028-z.
7
Smoldering and polarized inflammation in the initiation and promotion of malignant disease.隐匿性和极化性炎症在恶性疾病的起始和进展过程中的作用
Cancer Cell. 2005 Mar;7(3):211-7. doi: 10.1016/j.ccr.2005.02.013.
8
Chronic prostatitis: epidemiology and role of infection.慢性前列腺炎：流行病学及感染的作用
Urology. 2002 Dec;60(6 Suppl):8-12; discussion 13. doi: 10.1016/s0090-4295(02)02294-x.
9
Prostatein or steroid binding protein (PSBP) induces experimental autoimmune prostatitis (EAP) in NOD mice.前列腺素或类固醇结合蛋白（PSBP）可诱导非肥胖糖尿病（NOD）小鼠发生实验性自身免疫性前列腺炎（EAP）。
Clin Immunol. 2002 Nov;105(2):176-84. doi: 10.1006/clim.2002.5281.
10
A T-cell functional phenotype common among autoimmune-prone rodent strains.一种在自身免疫易感啮齿动物品系中常见的T细胞功能表型。
Scand J Immunol. 2002 Jun;55(6):546-59. doi: 10.1046/j.1365-3083.2002.01086.x.
Zotero 插件