Deng Longsheng, Zhang Xikui, Zhu Weikun, Lu Taikun, Chen Jinchun, Zou Qiang, Zheng Qizhong, Chen Junying, Jiang Changming, Jin Guanyu
Department of Andrology, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, China.
Department of Clinical Foundation of TCM, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Evid Based Complement Alternat Med. 2017;2017:7312938. doi: 10.1155/2017/7312938. Epub 2017 Dec 21.
The present study aimed to investigate the therapeutic effects of the Chinese herbal medicine Yin Zhi Huang soup (YZS) in an experimental autoimmune prostatitis (EAP) rat model. In total, 48 rats were randomly divided into the following four groups ( = 12/group): saline group, pathological model group, Qianlietai group, and YZS group. We determined the average wet weight of the prostate tissue, the ratio of the wet weight of the prostate tissue to body weight, tumor necrosis factor-alpha (TNF-) levels in the blood serum, the expression of inducible nitric oxide synthase (iNOS) in the rats' prostate tissues, and the pathological changes in the prostate tissue using light microscopy. YZS reduced the rats' prostate wet weight, the ratio of the prostate wet weight to body weight, and TNF- levels in the blood serum and inhibited the expression of iNOS in the rats' prostate tissues ( < 0.05). Following YZS treatment, the pathological changes in the rats' prostates were improved compared with those in the model group ( < 0.05). Furthermore, YZS treatment reduced inflammatory changes in the prostate tissue. It also significantly suppressed proinflammatory cytokines, such as TNF-, and chemokines, such as iNOS, in the rat model of EAP.
本研究旨在探讨中药茵栀黄汤（YZS）对实验性自身免疫性前列腺炎（EAP）大鼠模型的治疗作用。总共48只大鼠被随机分为以下四组（每组n = 12）：生理盐水组、病理模型组、前列泰组和YZS组。我们测定了前列腺组织的平均湿重、前列腺组织湿重与体重的比值、血清中肿瘤坏死因子-α（TNF-α）水平、大鼠前列腺组织中诱导型一氧化氮合酶（iNOS）的表达以及使用光学显微镜观察前列腺组织的病理变化。YZS降低了大鼠前列腺湿重、前列腺湿重与体重的比值以及血清中TNF-α水平，并抑制了大鼠前列腺组织中iNOS的表达（P < 0.05）。YZS治疗后，与模型组相比，大鼠前列腺的病理变化得到改善（P < 0.05）。此外，YZS治疗减轻了前列腺组织的炎症变化。它还显著抑制了EAP大鼠模型中促炎细胞因子如TNF-α和趋化因子如iNOS。
