Favilli Alessandro, Acanfora Marta Maddalena, Bini Vittorio, Radicchi Roberta, Di Renzo Gian Carlo, Gerli Sandro
Department of Obstetrics and Gynecology, University of Perugia, S.M. della Misericordia Hospital , Perugia , Italy.
J Matern Fetal Neonatal Med. 2013 May;26(7):665-8. doi: 10.3109/14767058.2012.746658. Epub 2012 Dec 12.
The aim of this study is to investigate if advance maternal age is an independent risk factor for cesarean section in women induced with prostaglandins. Only patients with a single indication for induction of labor were considered.
A matched retrospective cohort study was conducted. A study group of 112 women aged 35 or older was enrolled. The control group included 216 women aged 34 or younger. Multivariate logistical regression models were fitted for the prediction of the cesarean section.
There were no statistically significant differences in characteristics of the patients in the study and control groups. However, a higher prevalence of nulliparous women was found in control group (p = 0.002). The indications of labor induction were homogeneous in the two groups. No significant differences were found in the route of delivery. The median time of labor was significantly shorter in the study group (p = 0.002), and the birth weight and the placental weight were significantly lower in the study group. Advanced maternal age and newborn weight were directly related, whereas time of labor, Bishop score and parity were inversely related to a higher cesarean rate.
When single indication of induction of labor with prostaglandins is considered, advanced maternal age represents a significant independent risk factor for cesarean delivery.
本研究旨在调查高龄产妇是否为使用前列腺素引产的女性剖宫产的独立危险因素。仅纳入有单一引产指征的患者。
进行一项匹配的回顾性队列研究。纳入112名年龄35岁及以上的女性作为研究组。对照组包括216名年龄34岁及以下的女性。采用多因素逻辑回归模型预测剖宫产。
研究组和对照组患者的特征无统计学显著差异。然而，对照组初产妇的比例更高（p = 0.002）。两组引产指征相同。分娩方式无显著差异。研究组的中位产程明显更短（p = 0.002），且研究组的出生体重和胎盘重量明显更低。高龄产妇与新生儿体重直接相关，而产程、Bishop评分和产次与较高的剖宫产率呈负相关。
当考虑使用前列腺素进行单一引产指征时，高龄产妇是剖宫产的一个重要独立危险因素。
