Department of Chemical Physiology, The Scripps Research Institute and the Center for Regenerative Medicine, La Jolla, California 92037, USA.
Nat Cell Biol. 2012 Nov;14(11):1114-21. doi: 10.1038/ncb2613.
Pluripotent stem cells (PSCs) express a distinctive set of microRNAs (miRNAs). Many of these miRNAs have similar targeting sequences and are predicted to regulate downstream targets cooperatively. These enriched miRNAs are involved in the regulation of the unique PSC cell cycle, and there is increasing evidence that they also influence other important characteristics of PSCs, including their morphology, epigenetic profile and resistance to apoptosis. Detailed studies of miRNAs and their targets in PSCs should help to parse the regulatory networks that underlie developmental processes and cellular reprogramming.
多能干细胞 (PSCs) 表达一组独特的 microRNAs (miRNAs)。这些 miRNAs 中的许多具有相似的靶序列,预计会协同调控下游靶标。这些丰富的 miRNAs 参与调控 PSC 独特的细胞周期,越来越多的证据表明它们也影响 PSCs 的其他重要特征,包括形态、表观遗传谱和抗凋亡能力。对 PSCs 中的 miRNAs 及其靶标的详细研究应该有助于解析发育过程和细胞重编程所依赖的调控网络。