1Hacettepe University, Department of Internal Medicine, Hematology Unit, Turkey.
J Renin Angiotensin Aldosterone Syst. 2013 Dec;14(4):308-14. doi: 10.1177/1470320312464677. Epub 2012 Nov 6.
There is preliminary evidence that the local renin-angiotensin system (RAS) could affect neoplastic hematopoiesis. The aim of this study is to search messenger RNA (mRNA) expressions of the essential RAS elements in myeloid and lymphoid hematological neoplastic disorders. Forty-six patients with newly diagnosed myeloid (AML, biphenotypic leukemia, CML) or lymphoid (CLL, NHL, B-ALL, T-ALL) hematological disorders were included in the study. In the lymphoid group, the median expression values of RENIN, ACE1, ACE2 and ANGIOTENSINOGEN (ANGTS) mRNAs were 1.96%, 0.42%, 0.00% and 0.00%, respectively; in the myeloid group, 0.73%, 1.55%, 0.04% and 0.006%, respectively. In the lymphoid group, RENIN levels were significantly higher (p = 0.001), whereas ACE1 and ACE2 levels were significantly higher in the myeloid group (p values were 0.013 and 0.010, respectively). ANGTS levels were similar in both groups. In patients with non-ALL lymphoid malignancies, RENIN expressions were significantly higher when compared to ALL patients (p = 0.004). All patients with active disease had significantly higher RENIN mRNA expression levels than patients without active disease (2.03% vs 0.30%) (p = 0.034). The result of our present study indicates that the activities of local RAS may differ in distinct disease states such as leukemia and lymphomas.
有初步证据表明，局部肾素-血管紧张素系统（RAS）可能影响肿瘤性造血。本研究旨在研究骨髓和淋巴血液系统恶性肿瘤中基本 RAS 元素的信使 RNA（mRNA）表达。本研究纳入 46 例新诊断的骨髓（AML、双表型白血病、CML）或淋巴（CLL、NHL、B-ALL、T-ALL）血液系统恶性肿瘤患者。在淋巴组中，RENIN、ACE1、ACE2 和 ANGIOGENIN（ANGTS）mRNA 的中位表达值分别为 1.96%、0.42%、0.00%和 0.00%；在骨髓组中，分别为 0.73%、1.55%、0.04%和 0.006%。在淋巴组中，RENIN 水平明显更高（p = 0.001），而 ACE1 和 ACE2 水平在骨髓组中明显更高（p 值分别为 0.013 和 0.010）。两组的 ANGTS 水平相似。在非 ALL 淋巴恶性肿瘤患者中，RENIN 表达明显高于 ALL 患者（p = 0.004）。所有活动期疾病患者的 RENIN mRNA 表达水平明显高于非活动期疾病患者（2.03%比 0.30%）（p = 0.034）。本研究结果表明，局部 RAS 的活性在白血病和淋巴瘤等不同疾病状态下可能不同。
