研究一种水解稳定半抗原和 Th1 佐剂对海洛因疫苗效果的影响。
Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance.
机构信息
Department of Chemistry, The Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
出版信息
J Med Chem. 2012 Dec 13;55(23):10776-80. doi: 10.1021/jm301262z. Epub 2012 Nov 15.
Abstract
We challenged the performance of our previous heroin vaccine with a similar vaccine containing a more hydrolytically stable hapten analogue and a Th1 adjuvant (CpG ODN). Our results indicate that the elements of our previous vaccine are essential for its anti-heroin potency, i.e., a chemically labile hapten and an exclusively Th2 humoral response elicited by alum. Such design elements are critical for producing next-generation heroin vaccines.
摘要
我们用一种含有更水解稳定半抗原类似物和 Th1 佐剂（CpG ODN）的类似疫苗来挑战我们之前的海洛因疫苗的性能。我们的结果表明，我们之前疫苗的要素对于其抗海洛因效力是必不可少的，即化学不稳定的半抗原和由明矾引起的完全 Th2 体液反应。这种设计要素对于生产下一代海洛因疫苗至关重要。
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