一锅法从羧酸和胺合成芳酰胺和二肽的机械化学合成。
One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines.
机构信息
Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, HR-10002 Zagreb, Croatia.
出版信息
Chem Commun (Camb). 2012 Dec 25;48(99):12100-2. doi: 10.1039/c2cc36613d. Epub 2012 Nov 8.
PMID:23135220
Abstract
Environmentally friendly one-pot synthesis of amides, bis-amides and dipeptides by mechanochemical carbodiimide-mediated coupling of carboxylic acids and amines is described; high reaction yields and simple aqueous work-up allow for the clean, practical and fast preparation of a variety of compounds containing the amide bond from readily accessible reagents.
摘要
本文描述了一种通过机械化学碳化二亚胺介导的羧酸和胺的偶联反应，实现酰胺、双酰胺和二肽的绿色一锅合成法；高反应收率和简单的水相后处理，使各种含有酰胺键的化合物能够从易得的试剂出发，通过清洁、实用和快速的方法制备。
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