IMT Mines Albi, UMR CNRS 5302, Centre Rapsodee, Campus Jarlard, Allée des Sciences, Université de Toulouse, CEDEX 09, 81013 Albi, France.
Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 0B8, Canada.
Molecules. 2021 Sep 18;26(18):5667. doi: 10.3390/molecules26185667.
Green Chemistry has become in the last two decades an increasing part of research interest. Nonconventional «green» sources for chemical reactions include micro-wave, mechanical mixing, visible light and ultrasound. 1,2,3-triazoles have important applications in pharmaceutical chemistry while their 1,2,4 counterparts are developed to a lesser extent. In the review presented here we will focus on synthesis of 1,2,3 and 1,2,4-triazole systems by means of classical and « green chemistry » conditions involving ultrasound chemistry and mechanochemistry. The focus will be on compounds/scaffolds that possess biological/pharmacophoric properties. Finally, we will also present the formal cycloreversion of 1,2,3-triazole compounds under mechanical forces and its potential use in biological systems.
在过去的二十年中，绿色化学已成为越来越多研究兴趣的一部分。化学反应的非常规“绿色”来源包括微波、机械混合、可见光和超声波。1,2,3-三唑在药物化学中有重要的应用，而其 1,2,4-三唑类似物的应用则相对较少。在本文综述中，我们将重点介绍通过经典和“绿色化学”条件（包括超声化学和机械化学）合成 1,2,3 和 1,2,4-三唑体系的方法。重点将放在具有生物/药效团性质的化合物/支架上。最后，我们还将介绍在机械力作用下 1,2,3-三唑化合物的正式环反转及其在生物系统中的潜在用途。
