XtalFluor-E，一种用于羧酸酰胺化的高效偶联试剂。
XtalFluor-E, an efficient coupling reagent for amidation of carboxylic acids.
机构信息
Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
出版信息
Org Lett. 2013 Feb 15;15(4):902-5. doi: 10.1021/ol400045d. Epub 2013 Feb 5.
PMID:23383604
Abstract
Amides were produced from carboxylic acids and amines by using XtalFluor-E as an activator. Even poorly reactive carboxylic acids can be transformed to amides. In addition, optically active amines and/or carboxylic acids were not epimerized/racemized during the process.
摘要
酰胺可以通过使用 XtalFluor-E 作为活化剂由羧酸和胺来制备。即使是反应性较差的羧酸也可以转化为酰胺。此外，在反应过程中，手性胺和/或羧酸不会发生外消旋化/消旋化。
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