Department of Pathology, Robert C. Byrd Health Sciences Center, West Virginia University, and Clinical Laboratory, West Virginia University Healthcare, Morgantown, West Virginia, USA.
J Clin Microbiol. 2013 Jan;51(1):311-3. doi: 10.1128/JCM.02735-12. Epub 2012 Nov 7.
Quantitative fecal lactoferrin was measured in 112 patients tested for toxigenic Clostridium difficile using glutamate dehydrogenase (GDH) and toxin immunoassays combined with tcdB PCR. Lactoferrin levels were higher in the GDH-positive/toxin-positive group (79 μg/ml) than in the GDH-positive/toxin-negative/PCR-positive (21 μg/ml) and the GDH-negative groups (13 μg/ml). Differences in fecal lactoferrin levels suggest variable presence or severity of C. difficile infection among toxin-positive and toxin-negative patients.
对 112 例使用谷氨酸脱氢酶(GDH)和毒素免疫测定与 tcdB PCR 联合检测产毒艰难梭菌的患者进行了定量粪便乳铁蛋白检测。GDH 阳性/毒素阳性组(79μg/ml)的乳铁蛋白水平高于 GDH 阳性/毒素阴性/PCR 阳性组(21μg/ml)和 GDH 阴性组(13μg/ml)。粪便乳铁蛋白水平的差异表明,毒素阳性和毒素阴性患者的艰难梭菌感染的存在或严重程度不同。