光控含香豆素聚二乙酰亚胺囊泡的分级组装与融合。

Photo-controlled hierarchical assembly and fusion of coumarin-containing polydiacetylene vesicles.

机构信息

CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, Key Laboratory of Optoelectronic Science and Technology in Anhui Province, University of Science and Technology of China, Hefei, Anhui 230026, P R China.

出版信息

Macromol Rapid Commun. 2013 Feb 12;34(3):274-9. doi: 10.1002/marc.201200620. Epub 2012 Nov 8.

DOI:10.1002/marc.201200620

PMID:23136131

Abstract

Herein, we synthesize a coumarin-substituted diacetylene monomer (CODA) and report the novel photo-controlled reversible assembly and disassembly behavior of the polymerized CODA (PCODA) vesicles. The photo-triggered dimerization and cleavage reactions of the coumarin groups within the surface of the adjacent PCODA vesicles can be utilized as the driving force to induce assembly and disassembly of PCODA vesicles. Moreover, the boundary of PCODA vesicles in the aggregates becomes more obscure when the irradiation time exceeds 30 min. Fusion occurs upon close docking of target membranes, driven by sufficient dimerization of the coumarin groups within the surface of PCODA vesicles.

摘要

在这里，我们合成了一种香豆素取代的二乙炔单体（CODA），并报道了聚合 CODA（PCODA）囊泡的新型光控可逆组装和拆卸行为。香豆素基团在相邻 PCODA 囊泡表面的光触发二聚和裂解反应可以作为驱动力，诱导 PCODA 囊泡的组装和拆卸。此外，当照射时间超过 30 分钟时，聚集物中 PCODA 囊泡的边界变得更加模糊。当 PCODA 囊泡表面的香豆素基团充分二聚化时，通过靶膜的紧密对接发生融合。