Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan.
J Prosthodont Res. 2012 Oct;56(4):229-48. doi: 10.1016/j.jpor.2012.10.001. Epub 2012 Nov 6.
New technologies that facilitate solid alveolar ridge augmentation are receiving considerable attention in the field of prosthodontics because of the growing requirement for esthetic and functional reconstruction by dental implant treatments. Recently, several studies have demonstrated potential advantages for stem-cell-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) are now an excellent candidate for tissue replacement therapies, and tissue engineering approaches and chair-side cellular grafting approaches using autologous MSCs represent the clinical state of the art for stem-cell-based alveolar bone regeneration. Basic studies have revealed that crosstalk between implanted donor cells and recipient immune cells plays a key role in determining clinical success that may involve the recently observed immunomodulatory properties of MSCs. Part II of this review first overviews progress in regenerative dentistry to consider the implications of the stem cell technology in dentistry and then highlights cutting-edge stem-cell-based alveolar bone regenerative therapies. Factors that affect stem-cell-based bone regeneration as related to the local immune response are then discussed. Additionally, pre-clinical stem cell studies for the regeneration of teeth and other oral organs as well as possible applications of MSC-based immunotherapy in dentistry are outlined. Finally, the marketing of stem cell technology in dental stem cell banks with a view toward future regenerative therapies is introduced.
新技术促进了实体牙槽嵴的增强，在口腔修复学领域受到了极大的关注，因为种植牙治疗对美观和功能重建的需求日益增长。最近，几项研究表明，干细胞疗法在再生治疗中有潜在的优势。间充质干细胞（MSCs）现在是组织替代疗法的优秀候选者，使用自体 MSCs 的组织工程方法和椅旁细胞移植方法代表了基于干细胞的牙槽骨再生的临床最新技术。基础研究表明，植入的供体细胞与受者免疫细胞之间的相互作用在决定临床成功方面起着关键作用，这可能涉及到最近观察到的 MSCs 的免疫调节特性。本综述的第二部分首先概述了再生牙科的进展，以考虑干细胞技术在牙科中的意义，然后重点介绍了前沿的基于干细胞的牙槽骨再生疗法。接着讨论了与局部免疫反应相关的影响基于干细胞的骨再生的因素。此外，概述了用于牙齿和其他口腔器官再生的临床前干细胞研究，以及基于 MSC 的免疫疗法在牙科中的可能应用。最后，介绍了牙科干细胞库中干细胞技术的商业化，以期实现未来的再生治疗。
