Man-Technology-Environment (MTM) Research Centre, Örebro University, SE-701 82 Örebro, Sweden.
Environ Int. 2013 Jan;51:8-12. doi: 10.1016/j.envint.2012.09.001. Epub 2012 Nov 6.
Levels of perfluorocarboxylates (PFCAs) in biological compartments have been known for some time but their transport routes and distribution patterns are not properly elucidated. The opinions diverge whether the exposure of the general population occurs indirect through precursors or direct via PFCAs. Previous results showed that ski wax technicians are exposed to levels up to 92 000 ng/m(3) of 8:2 fluorotelomer alcohol (FTOH) via air and have elevated blood levels of PFCAs. Blood samples were collected in 2007-2011 and analyzed for C(4)-C(18) PFCAs, 6:2, 8:2 and 10:2 unsaturated fluorotelomer acids (FTUCAs) and 3:3, 5:3 and 7:3 fluorotelomer acids (FTCAs) using UPLC-MS/MS. Perfluorooctanoic acid (PFOA) was detected in levels ranging from 1.90 to 628 ng/mL whole blood (wb). Metabolic intermediates 5:3 and 7:3 FTCA were detected in all samples at levels up to 6.1 and 3.9 ng/mL wb. 6:2, 8:2 and 10:2 FTUCAs showed maximum levels of 0.07, 0.64 and 0.11 ng/mL wb. Also, for the first time levels of PFHxDA and PFOcDA were detected in the human blood at mean concentrations up to 4.22 ng/mL wb and 4.25 ng/mL wb respectively. The aim of this study was to determine concentrations of PFCAs and FTOH metabolites in blood from ski wax technicians.
一段时间以来，人们已经了解了生物隔室中全氟羧酸（PFCAs）的水平，但它们的迁移途径和分布模式尚未得到充分阐明。对于一般人群是通过前体间接暴露还是直接通过 PFCAs 暴露，人们的看法存在分歧。先前的结果表明，滑雪蜡技术人员通过空气接触高达 92000ng/m3 的 8:2 氟代醇（FTOH），其血液中的 PFCAs 水平升高。2007-2011 年采集了血液样本，并用 UPLC-MS/MS 分析了 C（4）-C（18）PFCAs、6:2、8:2 和 10:2 不饱和氟代醇酸（FTUCAs）以及 3:3、5:3 和 7:3 氟代醇酸（FTCAs）。全氟辛酸（PFOA）在全血（wb）中的检测浓度范围为 1.90 至 628ng/ml。在所有样本中均检测到代谢中间产物 5:3 和 7:3 FTCAs，浓度高达 6.1 和 3.9ng/ml wb。6:2、8:2 和 10:2FTUCAs 的最高浓度分别为 0.07、0.64 和 0.11ng/ml wb。此外，首次在人体血液中检测到 PFHxDA 和 PFOcDA 的浓度，分别高达 4.22ng/ml wb 和 4.25ng/ml wb。本研究旨在测定滑雪蜡技术人员血液中 PFCAs 和 FTOH 代谢物的浓度。
