Man-Technology-Environment MTM Research Centre, Orebro University, SE-701 82 Orebro, Sweden.
Environ Sci Technol. 2010 Oct 1;44(19):7717-22. doi: 10.1021/es101951t.
Levels of perfluorinated carboxylates (PFCAs) in different environmental and biological compartments have been known for some time, but the routes of exposure still remain unclear. The opinions are divergent whether the exposure to general populations occurs mainly indirect through precursor compounds or direct via PFCAs. Previous results showed elevated blood levels of PFCAs in ski wax technicians compared to a general population. The objective of this follow-up study was to determine concentrations of PFCAs, perfluorosulfonates (PFSAs), and fluorotelomer alcohols (FTOHs), precursor compounds that are known to degrade to PFCAs, in air collected in the breathing zone of ski wax technicians during work. We collected air samples by using ISOLUTE ENV+ cartridges connected to portable air pumps with an air flow of 2.0 L min(-1). PFCAs C5-C11 and PFSAs C4, C6, C8, and C10 were analyzed using LC-MS/MS and FTOHs 6:2, 8:2, and 10:2 with GC-MS/MS. The results show daily inhalation exposure of 8:2 FTOH in μg/m(3) air which is up to 800 times higher than levels of PFOA with individual levels ranging between 830-255000 ng/m(3) air. This suggests internal exposure of PFOA through biotransformation of 8:2 FTOH to PFOA and PFNA in humans.
一段时间以来，人们已经了解了不同环境和生物隔室中全氟羧酸酯 (PFCAs) 的水平，但暴露途径仍不清楚。人们对一般人群的暴露是主要通过前体化合物间接发生，还是直接通过 PFCAs 发生存在分歧。先前的结果表明，与一般人群相比，滑雪蜡技术人员的血液中 PFCAs 水平升高。这项随访研究的目的是确定在滑雪蜡技术人员工作时在呼吸区采集的空气中 PFCAs、全氟磺酸 (PFSAs) 和氟调聚物醇 (FTOHs)（已知会降解为 PFCAs 的前体化合物）的浓度。我们使用与空气流量为 2.0 L min(-1) 的便携式空气泵相连的 ISOLUTE ENV+ 小柱收集空气样本。使用 LC-MS/MS 分析 PFCAs C5-C11 和 PFSAs C4、C6、C8 和 C10，并用 GC-MS/MS 分析 FTOHs 6:2、8:2 和 10:2。结果表明，每天以 μg/m(3)空气的浓度吸入 8:2 FTOH，这是 PFOA 水平的 800 倍以上，个体空气中的浓度范围在 830-255000 ng/m(3) 之间。这表明通过 8:2 FTOH 向 PFOA 和 PFNA 的生物转化，人体内部暴露于 PFOA。
