Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan.
Curr Drug Targets. 2012 Dec;13(14):1842-57. doi: 10.2174/138945012804545506.
Many epidemiological studies and a large number of experimental studies using a variety of animal models have observed that consumption or administration of green tea appears to exert cancer chemopreventive activity. Based on the results of numerous laboratory cell culture investigations, several mechanisms have been hypothesized to underlie the anti-cancer activity of green tea catechins, especially that of (-)-epigallocatechin-3-gallate (EGCG), the most abundant and active constituent in green tea. These mechanisms include promotion of anti-oxidant activity, inhibition of NF-κB and AP-1, regulation of the cell cycle, inhibition of receptor tyrosine kinase pathways, control of epigenetic modifications, and modulation of the immune system. Several recent interventional studies examining the anti-carcinogenic properties of green tea catechins in humans have yielded promising results that suggest the possibility of their application to human clinical trials. This review article analyzes the results of these studies to explicate the effects of consumption or administration of green tea and its constituents on malignancies observed to date and discuss future directions in this research field.
许多流行病学研究和大量使用各种动物模型的实验研究都观察到，饮用或摄入绿茶似乎具有抗癌化学预防作用。基于大量实验室细胞培养研究的结果，人们提出了几种机制来解释绿茶儿茶素的抗癌活性，特别是绿茶中含量最丰富、活性最强的 (-)-表没食子儿茶素-3-没食子酸酯（EGCG）的抗癌活性。这些机制包括促进抗氧化活性、抑制 NF-κB 和 AP-1、调节细胞周期、抑制受体酪氨酸激酶途径、控制表观遗传修饰和调节免疫系统。最近的几项干预性研究检查了绿茶儿茶素在人类中的抗癌特性，结果令人鼓舞，这表明它们有可能应用于人类临床试验。本文分析了这些研究的结果，阐明了迄今为止观察到的绿茶及其成分的摄入或摄入对恶性肿瘤的影响，并讨论了该研究领域的未来方向。
