The Brain Institute, University of Utah, 383 Colorow Drive, Salt Lake City, UT 84108, United States.
Psychiatry Res. 2012 Oct 30;204(1):32-9. doi: 10.1016/j.pscychresns.2012.09.009. Epub 2012 Nov 9.
The aim of this study was to evaluate whether structural differences in the insula and anterior cingulate cortex (ACC), two critical areas of the "salience network," co-exist in adolescents with attention deficit hyperactivity disorder (ADHD) compared with healthy controls (HC). In addition we aimed to determine if structural changes within these regions correlate with attention and inhibitory function. Nineteen adolescents with ADHD and 25 HC received MRI scans on a 3T magnet. Morphometric analysis was performed with FreeSurfer. Youths with ADHD were found to have a bilateral reduction in anterior insular (AIC) gray matter volumes compared to HC. Furthermore, the left AIC was found to positively correlate with oppositional symptoms, while the right AIC was found to associate with both attention problems and inhibition. To our knowledge this is the first report of a bilateral reduction in AIC volumes in ADHD. Our findings suggest a role for the insula in modulating attention and inhibitory capacity in ADHD.
本研究旨在评估与健康对照组（HC）相比，注意力缺陷多动障碍（ADHD）青少年是否存在岛叶和前扣带皮层（ACC）这两个“突显网络”关键区域的结构差异。此外，我们还旨在确定这些区域内的结构变化是否与注意力和抑制功能相关。19 名 ADHD 青少年和 25 名 HC 接受了 3T 磁共振成像（MRI）扫描。使用 FreeSurfer 进行形态计量学分析。与 HC 相比，ADHD 青少年的双侧前岛叶（AIC）灰质体积减少。此外，左侧 AIC 与对立症状呈正相关，而右侧 AIC 与注意力问题和抑制均相关。据我们所知，这是第一个报告 ADHD 中双侧 AIC 体积减少的报告。我们的研究结果表明岛叶在调节 ADHD 中的注意力和抑制能力方面发挥作用。
