突显网络在精神病中起关键作用吗？一个关于脑岛功能障碍的新兴假说。
Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction.
机构信息
Division of Psychiatry, University of Nottingham, Queen's Medical Centre, Nottingham, United Kingdom.
出版信息
J Psychiatry Neurosci. 2012 Jan;37(1):17-27. doi: 10.1503/jpn.100176.
Abstract
The insular cortex is one of the brain regions that show consistent abnormalities in both structural and functional neuroimaging studies of schizophrenia. In healthy individuals, the insula has been implicated in a myriad of physiologic functions. The anterior cingulate cortex (ACC) and insula together constitute the salience network, an intrinsic large-scale network showing strong functional connectivity. Considering the insula as a functional unit along with the ACC provides an integrated understanding of the role of the insula in information processing. In this review, we bring together evidence from imaging studies to understand the role of the salience network in schizophrenia and propose a model of insular dysfunction in psychosis.
摘要
脑岛是精神分裂症的结构和功能神经影像学研究中一致显示异常的大脑区域之一。在健康个体中，脑岛与许多生理功能有关。扣带前回（ACC）和脑岛共同构成突显网络，这是一个具有强大功能连接的内在大规模网络。将脑岛视为与 ACC 一起的功能单元，可以提供对脑岛在信息处理中的作用的综合理解。在这篇综述中，我们结合影像学研究的证据来理解突显网络在精神分裂症中的作用，并提出一个精神疾病中脑岛功能障碍的模型。
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