碘化钾催化的吲哚与 4-取代-N,N-二甲基苯胺的 C3 甲酰化和 N-氨甲基化的同时反应。
Potassium iodide catalyzed simultaneous C3-formylation and N-aminomethylation of indoles with 4-substituted-N,N-dimethylanilines.
机构信息
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, 94 Weijin Road, Tianjin 300071, China.
出版信息
Org Biomol Chem. 2012 Dec 28;10(48):9519-22. doi: 10.1039/c2ob26636a. Epub 2012 Nov 12.
PMID:23143045
Abstract
A one-pot dual functionalization of indoles has been developed. The simultaneous C3-formylation and N-aminomethylation of indoles can be achieved using readily available potassium iodide as a catalyst and tert-butyl peroxybenzoate as a co-oxidant.
摘要
吲哚的一锅两步官能化反应已经被开发出来。使用易得的碘化钾作为催化剂和叔丁基过氧苯甲酸酯作为共氧化剂，可以实现吲哚的 C3 甲酰化和 N-甲胺基化的同时进行。
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