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额前区域的“什么”和“哪里”记忆的分化顶叶连接。

Differentiated parietal connectivity of frontal regions for "what" and "where" memory.

机构信息

Institute for Neuroscience and Medicine (INM-1, INM-2, INM-4), Research Center Jülich, Leo-Brandt Str. 5, 52425, Jülich, Germany.

出版信息

Brain Struct Funct. 2013 Nov;218(6):1551-67. doi: 10.1007/s00429-012-0476-4. Epub 2012 Nov 10.

Abstract

In a previous meta-analysis across almost 200 neuroimaging experiments, working memory for object location showed significantly stronger convergence on the posterior superior frontal gyrus, whereas working memory for identity showed stronger convergence on the posterior inferior frontal gyrus (dorsal to, but overlapping with Brodmann's area BA 44). As similar locations have been discussed as part of a dorsal frontal-superior parietal reach system and an inferior frontal grasp system, the aim of the present study was to test whether the regions of working-memory related "what" and "where" processing show a similar distinction in parietal connectivity. The regions that were found in the previous meta-analysis were used as seeds for functional connectivity analyses using task-based meta-analytic connectivity modelling and task-independent resting state correlations. While the ventral seed showed significantly stronger connectivity with the bilateral intraparietal sulcus (IPS), the dorsal seed showed stronger connectivity with the bilateral posterior inferior parietal and the medial superior parietal lobule. The observed connections of regions involved in memory for object location and identity thus clearly demonstrate a distinction into separate pathways that resemble the parietal connectivity patterns of the dorsal and ventral premotor cortex in non-human primates and humans. It may hence be speculated that memory for a particular location and reaching towards it as well as object memory and finger positioning for manipulation may rely on shared neural systems. Moreover, the ensuing regions, in turn, featured differential connectivity with the bilateral ventral and dorsal extrastriate cortex, suggesting largely segregated bilateral connectivity pathways from the dorsal visual cortex via the superior and inferior parietal lobules to the dorsal posterior frontal cortex and from the ventral visual cortex via the IPS to the ventral posterior frontal cortex that may underlie action and cognition.

摘要

在之前一项涉及近 200 项神经影像学实验的荟萃分析中,物体位置的工作记忆在后部上额回上的收敛性明显更强,而身份的工作记忆在后部下额回(位于但与布罗德曼区 BA44 重叠的背侧)上的收敛性更强。由于类似的位置被认为是背侧额叶-上顶叶延伸系统和下额叶抓握系统的一部分,本研究的目的是测试与工作记忆相关的“什么”和“哪里”处理的区域在顶叶连接中是否表现出类似的区别。在前一项荟萃分析中发现的区域被用作功能连接分析的种子,使用基于任务的荟萃分析连接建模和任务独立的静息状态相关性。虽然腹侧种子与双侧顶内沟(IPS)的连接明显更强,而背侧种子与双侧下顶叶和内侧上顶叶的连接更强。因此,所观察到的与物体位置和身份记忆相关的区域的连接清楚地表明了一种区分,形成了类似于非人类灵长类动物和人类背侧和腹侧前运动皮层的顶叶连接模式的独立途径。因此,可以推测,对特定位置的记忆以及对其的到达、物体记忆和用于操作的手指定位可能依赖于共享的神经系统。此外,随后的区域反过来与双侧腹侧和背侧外纹状体的连接也存在差异,这表明从背侧视觉皮层经上顶叶和下顶叶到背侧额后皮质以及从腹侧视觉皮层经 IPS 到腹侧额后皮质的双侧连接途径存在很大的分离,这些连接途径可能是行动和认知的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbef/3825581/fd99933592b5/429_2012_476_Fig1_HTML.jpg

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