红细胞分布宽度可预测部分乳糜泻患者的肠萎缩。
Red cell distribution width can predict intestinal atrophy in selected patients with celiac disease.
机构信息
Department of Gastroenterology, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey.
出版信息
J Clin Lab Anal. 2012 Nov;26(6):497-502. doi: 10.1002/jcla.21553.
BACKGROUND
Red cell distribution width (RDW) has been shown as a distinctive marker of mortality and morbidity in a wide spectrum of conditions related to systemic inflammation or deficiency of antioxidant nutrients.
OBJECTIVE
We aimed to investigate the predictive value of RDW in detection of intestinal atrophy in celiac disease (CD).
METHODS
Iron indices and RDW were studied in 49 patients with CD to evaluate the utilization of RDW as a predictive marker for presence of intestinal atrophy.
RESULTS
Sixty-nine percent of patients had iron deficiency at initial presentation and 89% had abnormal RDW defined as >14. Receiver operating characteristics curves of RDW has been found to be a predictive of intestinal atrophy at levels higher than 17.25 (68% sensitivity and 85% specificity). In patients with transglutaminase antibody IgA titers >200 U/l, RDW level >17.75 showed 76% sensitivity and 100% specificity for intestinal atrophy.
CONCLUSIONS
We suggest that RDW can be used as a surrogate marker of atrophy in patients with iron deficiency and suspected CD. In addition, the sensitivity, specificity, negative and positive predictive values of RDW increases when used in combination with high levels of transglutaminase IgA antibody.
背景
红细胞分布宽度（RDW）已被证明是与全身炎症或抗氧化营养素缺乏相关的广泛疾病条件下死亡率和发病率的独特标志物。
目的
我们旨在研究 RDW 在检测乳糜泻（CD）中肠萎缩的预测价值。
方法
对 49 例 CD 患者的铁指标和 RDW 进行研究，以评估 RDW 作为肠萎缩存在的预测标志物的应用价值。
结果
69%的患者在初诊时存在缺铁，89%的患者 RDW 异常（定义为>14）。RDW 的受试者工作特征曲线被发现可预测肠萎缩，其水平高于 17.25（68%的敏感性和 85%的特异性）。在转谷氨酰胺酶抗体 IgA 滴度>200 U/l 的患者中，RDW 水平>17.75 对肠萎缩的敏感性为 76%，特异性为 100%。
结论
我们认为，RDW 可作为缺铁和疑似 CD 患者萎缩的替代标志物。此外，当与高水平的转谷氨酰胺酶 IgA 抗体联合使用时，RDW 的敏感性、特异性、阴性和阳性预测值增加。
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