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长基因组 DNA 扩增子吸附在未经修饰的金纳米粒子上，用于炭疽杆菌的比色检测。

Long genomic DNA amplicons adsorption onto unmodified gold nanoparticles for colorimetric detection of Bacillus anthracis.

机构信息

CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, 11 Beiyijie, Zhongguancun, Beijing 100190, China.

出版信息

Chem Commun (Camb). 2013 Jan 4;49(1):51-3. doi: 10.1039/c2cc37037a. Epub 2012 Nov 12.

DOI:10.1039/c2cc37037a
PMID:23145437
Abstract

Unmodified gold nanoparticles (GNPs) can be wrapped with long genomic single- and double-stranded DNA (ssDNA and dsDNA) molecules produced by asymmetric polymerase chain reaction (As-PCR). More importantly, the DNA-Au interaction can be utilized for colorimetric detection of a specific nucleic acid sequence in clinical samples.

摘要

未经修饰的金纳米粒子（GNPs）可以被不对称聚合酶链反应（As-PCR）产生的长基因组单链和双链 DNA（ssDNA 和 dsDNA）分子包裹。更重要的是，DNA-Au 相互作用可用于临床样本中特定核酸序列的比色检测。

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