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内耳药物递送系统的合理设计

Rational Design of Inner Ear Drug Delivery Systems.

作者信息

Maimaitikelimu Xiayidan, Xuan Zhiyan, Ren Haoyu, Chen Keng, Zhang Hui, Wang Huan

机构信息

The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518033, China.

School of Life Sciences and Technology, Southeast University, Nanjing, 210000, China.

出版信息

Adv Sci (Weinh). 2025 Aug;12(29):e2410568. doi: 10.1002/advs.202410568. Epub 2025 May 8.

DOI:10.1002/advs.202410568
PMID:40344640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12362808/
Abstract

The number of people with hearing loss disorders is enormous, causing great physical and mental stress to patients, as well as a huge social burden. Among these patients, hearing loss caused by inner ear lesions accounts for a large proportion. Therefore, treatment of the inner ear is important. Inner ear drug delivery systems, which can reduce the side effects of systemic drug administration by delivering drugs directly to the inner ear, are important in sensorineural hearing loss. Here, the development of inner ear drug delivery systems is focused, including the complex physiological structure that they face, types of drugs delivered, routes of administration, and forms of drug delivery carrier platforms. Recent studies in this process are presented and it is concluded with a summary and outlook on the problems faced and possible solutions.

摘要

听力损失障碍患者数量庞大，给患者带来了巨大的身心压力，也造成了沉重的社会负担。在这些患者中，内耳病变导致的听力损失占很大比例。因此，内耳治疗至关重要。内耳给药系统可通过将药物直接输送到内耳来减少全身给药的副作用，在感音神经性听力损失治疗中具有重要意义。本文重点介绍内耳给药系统的发展，包括它们所面临的复杂生理结构、所输送药物的类型、给药途径以及药物输送载体平台的形式。文中展示了这一过程中的最新研究，并对所面临的问题及可能的解决方案进行了总结和展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/4f0d40ec54fa/ADVS-12-2410568-g016.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/627c2ad80093/ADVS-12-2410568-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/b0116cbfa296/ADVS-12-2410568-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/3e6bdb88c3c2/ADVS-12-2410568-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/83a07c08b849/ADVS-12-2410568-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/5c2baf5bc52b/ADVS-12-2410568-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/844a3c2cb2aa/ADVS-12-2410568-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/58273afab7b7/ADVS-12-2410568-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/c6a7da77e7e6/ADVS-12-2410568-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/4f0d40ec54fa/ADVS-12-2410568-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/e19f9fc225d8/ADVS-12-2410568-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/b7359eb9c49b/ADVS-12-2410568-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/c2496a8ab39c/ADVS-12-2410568-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/627c2ad80093/ADVS-12-2410568-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/b0116cbfa296/ADVS-12-2410568-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/3e6bdb88c3c2/ADVS-12-2410568-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/83a07c08b849/ADVS-12-2410568-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/5c2baf5bc52b/ADVS-12-2410568-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/844a3c2cb2aa/ADVS-12-2410568-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/58273afab7b7/ADVS-12-2410568-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/c6a7da77e7e6/ADVS-12-2410568-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8233/12362808/4f0d40ec54fa/ADVS-12-2410568-g016.jpg

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Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction.用于听力重建的新兴生物技术和生物医学工程技术。
Smart Med. 2023 Oct 27;2(4):e20230021. doi: 10.1002/SMMD.20230021. eCollection 2023 Nov.
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Editorial: Identifying novel drug delivery systems and treatments for hearing loss and related ear disorders, volume II.
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Front Pharmacol. 2024 Jul 29;15:1464254. doi: 10.3389/fphar.2024.1464254. eCollection 2024.
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Crosslinked-hybrid nanoparticle embedded in thermogel for sustained co-delivery to inner ear.交联杂化纳米粒子嵌入温敏水凝胶中用于内耳的持续共递送。
J Nanobiotechnology. 2024 Aug 13;22(1):482. doi: 10.1186/s12951-024-02686-z.
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A base editor for the long-term restoration of auditory function in mice with recessive profound deafness.一种用于长期恢复隐性重度耳聋小鼠听觉功能的碱基编辑器。
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