Martín-Rodríguez A, Pérez-San-Gregorio M A, Domínguez-Cabello E, Fernández-Jiménez E, Pérez Bernal J
Faculty of Psychology, Department of Personality, Assessment, and Psychological Treatments, University of Seville, Seville, Spain.
Transplant Proc. 2012 Nov;44(9):2619-21. doi: 10.1016/j.transproceed.2012.09.052.
We aimed to determine whether there were differences with regard to anxiety and depressive symptomatology between liver transplant recipients with better (G(1)) versus worse (G(2)) self-perceptions of general health compared with pre-liver transplantation cirrhotic patients (G(3)).
The groups of patients included 168 recipients including 85 and 83 with better or worse self-perceptions of general health, respectively, and 75 cirrhotic pre-liver transplantation patients. For the psychological assessment we used the Hospital Anxiety and Depression Scale and the general health dimension of the SF-36 Health Questionnaire. The following analyses were used: Analysis of variance (ANOVA) with post hoc pairwise comparisons by means of Tukey's test and Cohen's d, an effect size index.
Significant differences were observed among the three groups for the variables of anxiety (P = .000) and depression (P = .000). Specifically, liver transplant recipients with better self-perceptions of general health displayed lower scores (better mental health) compared with those showing worse self-perceptions or cirrhotic patients. There were no differences between the latter two groups. The differences in these variables were relevant (large effect sizes) for anxiety (Cohen's d(1-2) = -1.075, Cohen's d(1-3) = -1.155) and for depression (Cohen's d(1-2) = -1.145, Cohen's d(1-3) = -1.158).
The anxious-depressive status was not necessarily better among liver transplant recipients. There was great variability among them as a function of self-perceived general health. Transplant recipients with worse self-perception of general health presented the same anxiety-depressive levels as patients with severe liver disease in the pretransplantation phase; the latter groups reach the clinical threshold on the depression scale.
我们旨在确定与肝移植前肝硬化患者（G3组）相比，自我感知总体健康状况较好（G1组）与较差（G2组）的肝移植受者在焦虑和抑郁症状方面是否存在差异。
患者组包括168例肝移植受者，其中分别有85例和83例自我感知总体健康状况较好或较差，以及75例肝移植前肝硬化患者。对于心理评估，我们使用了医院焦虑抑郁量表和SF-36健康问卷的总体健康维度。采用以下分析方法：方差分析（ANOVA），并通过Tukey检验和效应量指数Cohen's d进行事后两两比较。
在焦虑（P = .000）和抑郁（P = .000）变量上，三组之间观察到显著差异。具体而言，与自我感知较差的肝移植受者或肝硬化患者相比，自我感知总体健康状况较好的肝移植受者得分较低（心理健康状况较好）。后两组之间没有差异。这些变量在焦虑（Cohen's d(1-2) = -1.075，Cohen's d(1-3) = -1.155）和抑郁（Cohen's d(1-2) = -1.145，Cohen's d(1-3) = -1.158）方面的差异具有相关性（效应量较大）。
肝移植受者的焦虑抑郁状态不一定更好。根据自我感知的总体健康状况，他们之间存在很大差异。自我感知总体健康状况较差的移植受者的焦虑抑郁水平与移植前严重肝病患者相同；后一组在抑郁量表上达到临床阈值。
