Fallet G H, Micheli A
Bull Schweiz Akad Med Wiss. 1979 Sep;35(4-6):403-20.
Articular chondrocalcinosis results from the deposits of calcium pyrophosphate microcrystals in the articular hyalin and fibrocartilages, the synovium and at times the tendons. In our area it is seen most frequently as isolated cases in the elderly and may be asymptomatic. When the affected joints present clinical manifestations, they vary from acute to subacute or chronic recurrent arthritis. A marked articular destruction can be observed in some cases. There is a classical radiological picture: linear opacities are most frequently seen localized in the mid-zone layer of the hyalin cartilage running parallel to but at a certain distance from the bone cortex. A part of our research has shown that in contrast to urate gout, articular chondrocalcinosis results from a metabolic disturbance of the calcium pyrophosphate localized almost exclusively in the same articular structures. Precise information is lacking at the present time to explain why calcium pyrophosphate mycrocrystals accumulate in the cartilage, the synovium and at times at the tendons; nor do we understand the precise role played by the pyrophosphate in bone and cartilage destruction.
关节软骨钙质沉着症是由焦磷酸钙微晶沉积于关节透明软骨和纤维软骨、滑膜，有时也沉积于肌腱所致。在我们地区，它最常见于老年人的孤立病例，可能无症状。当受累关节出现临床表现时，可从急性转变为亚急性或慢性复发性关节炎。在某些病例中可观察到明显的关节破坏。有典型的放射学表现：线性不透光区最常见于透明软骨中层，与骨皮质平行但有一定距离。我们的部分研究表明，与尿酸盐痛风不同，关节软骨钙质沉着症几乎完全由局限于相同关节结构的焦磷酸代谢紊乱引起。目前缺乏确切信息来解释为什么焦磷酸钙微晶会在软骨、滑膜以及有时在肌腱中积聚；我们也不了解焦磷酸在骨和软骨破坏中的确切作用。
