Ther Adv Endocrinol Metab. 2010 Apr;1(2):89-94. doi: 10.1177/2042018810375812.
Metabolic syndrome refers to a clustering of established and emerging cardiovascular disease risk factors within a single individual. The established risk factors, such as obesity, diabetes, dyslipidaemia and hypertension, and other emerging risk factors are closely related to central obesity (especially intra-abdominal adiposity) and insulin resistance. However, debate continues about the very existence of the metabolic syndrome. Despite the controversies, many existing and new therapies are targeting the metabolic syndrome and component risk factors. To date, no therapies have been approved specifically for treating the metabolic syndrome. In this article some of the challenges and opportunities in developing therapies for the metabolic syndrome are discussed.
代谢综合征是指个体中存在多种已确立和新兴的心血管疾病危险因素。这些已确立的危险因素，如肥胖、糖尿病、血脂异常和高血压，以及其他新兴的危险因素，与中心性肥胖（尤其是内脏型肥胖）和胰岛素抵抗密切相关。然而，代谢综合征的存在仍然存在争议。尽管存在争议，但许多现有的和新的治疗方法都针对代谢综合征及其组成的危险因素。迄今为止，尚无专门用于治疗代谢综合征的疗法获得批准。本文讨论了开发代谢综合征治疗方法所面临的一些挑战和机遇。
