海洋蓝细菌天然产物 4-O-去甲巴卡亭 III 的异源生物合成。
Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product.
机构信息
Department of Chemistry and Nano Sciences, Ewha Womans University, Seoul 120-750, Republic of Korea.
出版信息
Org Lett. 2012 Dec 7;14(23):5824-7. doi: 10.1021/ol302575h. Epub 2012 Nov 13.
Abstract
Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.
摘要
海洋蓝细菌 Moorea producens 的 barbamide 生物合成基因簇在陆地放线菌 Streptomyces venezuelae 中的异源表达导致了一种新的 barbamide 同系物 4-O-去甲 barbamide 的产生，证明了这种方法在研究复杂海洋天然产物的组装和修饰方面的潜力。
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