Department of Dermatology, Mayo Clinic, Scottsdale, AZ 85259, USA.
J Cutan Med Surg. 2012 Nov-Dec;16(6):428-32. doi: 10.1177/120347541201600612.
Nerve involvement developed in a patient with granuloma annulare, as evidenced by a perineural infiltrate of histiocytes in the dermis. The histopathologic pattern was suggestive of leprosy. No mycobacteria were observed, and neurologic testing was normal.
To determine whether inflammation of the nerves or perineural tissue is common in granuloma annulare, we studied the cutaneous nerves in skin biopsy specimens from 14 patients with granuloma annulare.
Sections were stained with hematoxylin-eosin to highlight inflammatory cells and with S-100 to identify cutaneous nerves.
No inflammation around nerves was found in 12 specimens, abutting granulomatous inflammation was found in 1 specimen, and enveloping granulomatous inflammation was found in 1 specimen. No nerves were infiltrated by inflammatory cells.
Perineural granulomatous inflammation resembling the perineural infiltrate of leprosy appears to be an uncommon characteristic of granuloma annulare. Clinical correlation and acid-fast stains can assist in establishing the correct diagnosis.
一位肉芽肿性环状红斑患者出现神经受累，真皮内组织细胞呈神经周围浸润，提示可能为麻风病。未观察到分枝杆菌，神经学检查正常。
为明确神经或神经周围组织的炎症在肉芽肿性环状红斑中是否常见，我们研究了 14 例肉芽肿性环状红斑患者皮肤活检标本中的皮肤神经。
用苏木精-伊红染色突出炎性细胞，用 S-100 染色识别皮肤神经。
12 例标本未见神经周围炎症，1 例标本紧邻肉芽肿性炎症，1 例标本包绕肉芽肿性炎症。未见炎性细胞浸润神经。
类似于麻风病神经周围浸润的神经周围肉芽肿性炎症似乎是肉芽肿性环状红斑的一种不常见特征。临床相关性和抗酸染色有助于确立正确的诊断。
