逆转糖尿病肾病内皮功能障碍的策略。
Strategies to reverse endothelial dysfunction in diabetic nephropathy.
机构信息
Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Kidney Int. 2012 Dec;82(11):1151-4. doi: 10.1038/ki.2012.306.
Abstract
Endothelial dysfunction underlies the basic pathophysiology of microvascular complications of diabetes. Endothelial dysfunction is associated with impaired nitric oxide (NO) availability. Since NO production is tightly regulated by endothelial nitric oxide synthase (eNOS), several therapeutic strategies have been investigated and proposed to improve eNOS bioavailability in the vasculature. The findings of Cheng et al. suggest that increased availability of eNOS may be an effective strategy in restoring endothelial function in patients with diabetic nephropathy.
摘要
内皮功能障碍是糖尿病微血管并发症的基本病理生理学基础。内皮功能障碍与一氧化氮（NO）供应受损有关。由于 NO 的产生受到内皮型一氧化氮合酶（eNOS）的严格调节，因此已经研究并提出了几种治疗策略来改善血管中 eNOS 的生物利用度。程等人的研究结果表明，增加 eNOS 的可用性可能是恢复糖尿病肾病患者内皮功能的有效策略。
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Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice.改善内皮型一氧化氮合酶活性可延缓 db/db 小鼠糖尿病肾病的进展。
Kidney Int. 2012 Dec;82(11):1176-83. doi: 10.1038/ki.2012.248. Epub 2012 Jul 11.
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