用N-乙基-N-羟乙基亚硝胺处理的大鼠肾小管细胞瘤的组织病理学研究。
Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
作者信息
Hiasa Y, Ohshima M, Iwata C, Tanikake T
出版信息
Gan. 1979 Dec;70(6):817-20.
PMID:231537
Abstract
Administration of a diet containing 0.2% N-ethyl-N-hydroxyethylnitrosamine (EHEN) for 2 weeks induced hepatocellular carcinoma in 3 and renal tubular cell tumors in 7 of 9 Wistar rats. Diet containing 0.1% EHEN induced renal tubular cell tumors in 6 of 10 rats, but no hepatocellular carcinomas. Both diets induced atypical cell population of tubules in the kidney, but no nephroblastoma.
摘要
给9只Wistar大鼠喂食含0.2% N-乙基-N-羟乙基亚硝胺（EHEN）的饲料2周，其中3只诱发了肝细胞癌，7只诱发了肾小管细胞瘤。含0.1% EHEN的饲料使10只大鼠中的6只诱发了肾小管细胞瘤，但未诱发肝细胞癌。两种饲料均诱发了肾脏肾小管的非典型细胞群，但未诱发肾母细胞瘤。
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