Hirose M, Shirai T, Tsuda H, Fukushima S, Ogiso T, Ito N
Carcinogenesis. 1981;2(12):1299-302. doi: 10.1093/carcin/2.12.1299.
The effects of phenobarbital (PB), polychlorinated biphenyl (PCB) and sodium saccharin (SS) on hepatic and renal carcinogenesis induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) were examined in male F344 rats. The rats were given 0.1% EHEN in their drinking water for 2 weeks and then diet containing 0.05% PB, 0.05% PCB or 5% SS for 32 weeks. In week 3, the right kidney was removed to promote renal neoplasia. The incidence of hepatocellular carcinoma was much higher in rats given PB or PCB than in controls given EHEN alone. PB administration significantly decreased the average number of renal-cell tumors per unit area and SS reduced the numbers of early neoplastic nodules. Treatment with PCB had no effect on renal carcinogenesis. These results indicate that chemicals may have either a promotive or inhibitory effect depending on the organ.
在雄性F344大鼠中，研究了苯巴比妥（PB）、多氯联苯（PCB）和糖精钠（SS）对N-乙基-N-羟乙基亚硝胺（EHEN）诱导的肝脏和肾脏致癌作用的影响。给大鼠饮用含0.1% EHEN的水2周，然后给予含0.05% PB、0.05% PCB或5% SS的饲料32周。在第3周时，切除右肾以促进肾肿瘤形成。给予PB或PCB的大鼠肝细胞癌的发生率比单独给予EHEN的对照组高得多。给予PB显著降低了单位面积肾细胞肿瘤的平均数量，而SS减少了早期肿瘤结节的数量。PCB处理对肾脏致癌作用没有影响。这些结果表明，化学物质可能根据器官不同而具有促进或抑制作用。
