Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA.
Virulence. 2012 Nov 15;3(7):647-53. doi: 10.4161/viru.22491.
Dendritic cells (DC) are a heterogeneous population of innate immune cells that are fundamental to initiating responses against invading pathogens and regulating immune responses. Myeloid DC (mDC) act as a bridge between the innate and adaptive immune response during virus infections but their role in immunity to human immunodeficiency virus (HIV) remains ill-defined. This review examines aspects of the mDC response to HIV and its simian counterpart, simian immunodeficiency virus (SIV), and emphasizes areas where our knowledge of mDC biology and function is incomplete. Defining the potentially beneficial and detrimental roles mDC play during pathogenic and stable infection of humans and nonhuman primates is crucial to our overall understanding of AIDS pathogenesis.
树突状细胞（DC）是先天免疫系统中具有异质性的细胞群体，对于引发针对入侵病原体的反应和调节免疫反应至关重要。髓样树突状细胞（mDC）在病毒感染期间充当先天免疫和适应性免疫反应之间的桥梁，但它们在人类免疫缺陷病毒（HIV）免疫中的作用仍未明确界定。本综述探讨了 mDC 对 HIV 和其灵长类对应物，即猿猴免疫缺陷病毒（SIV）的反应的各个方面，并强调了我们对 mDC 生物学和功能认识不完整的领域。确定 mDC 在致病性和稳定感染人类和非人类灵长类动物期间所起的有益和有害作用，对于我们全面理解艾滋病发病机制至关重要。
