Boudreau R J, Strony J T, duCret R P, Kuni C C, Wang Y, Wilson R F, Schwartz J S, Castaneda-Zuniga W R
Department of Radiology, University of Minnesota Hospital and Clinics, Minneapolis 55455.
Radiology. 1990 Apr;175(1):103-5. doi: 10.1148/radiology.175.1.2315467.
Eighty patients with type I diabetes and end stage renal disease were prospectively evaluated for coronary artery disease with dipyridamole-thallium-201 scintigraphy and quantitative coronary angiography. Forty patients received dipyridamole orally, and 40 received it intravenously. The prevalence of coronary artery disease was 53%. There were no significant differences in the accuracy of the two dipyridamole tests (sensitivity = 85%, specificity = 85%, accuracy = 85% for the oral group; sensitivity = 86%, specificity = 72%, accuracy = 79% for the intravenous group). Combining the 80 patients into a single group gave a sensitivity of 86%, a specificity of 79%, and an accuracy of 83% for the detection of coronary disease. Although the accuracy of this test in this patient population was similar to that previously reported for other groups, the prevalence of disease was high and resulted in a low predictive value of a negative test (83%).
对80例I型糖尿病合并终末期肾病患者进行前瞻性研究，采用双嘧达莫-铊-201闪烁扫描和定量冠状动脉造影评估冠状动脉疾病。40例患者口服双嘧达莫，40例患者静脉注射双嘧达莫。冠状动脉疾病的患病率为53%。两种双嘧达莫试验的准确性无显著差异（口服组敏感性=85%，特异性=85%，准确性=85%；静脉注射组敏感性=86%，特异性=72%，准确性=79%）。将80例患者合并为一组，检测冠状动脉疾病的敏感性为86%，特异性为79%，准确性为83%。虽然该试验在该患者群体中的准确性与先前报道的其他群体相似，但疾病患病率较高，导致阴性试验的预测价值较低（83%）。
