Sether L A, Nguyen C, Yu S N, Haughton V M, Ho K C, Biller D S, Strandt J A, Eurell J C
Department of Anatomy, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee 53226.
Radiology. 1990 Apr;175(1):207-11. doi: 10.1148/radiology.175.1.2315482.
Because the structure, maturation, and degeneration of canine intervertebral disks resemble those of humans, the authors developed a model of acute intervertebral disk degeneration in dogs. Herniated disks of 18 dogs were examined with magnetic resonance (MR) imaging and then sectioned with a freezing microtome. On the basis of their morphologic appearance in the freezing microtome sections, most of the lumbar intervertebral disks could be categorized as one of six types. Each type has characteristic features and a distinctive appearance on MR images. Findings of this study--including decreased signal intensity from the intervertebral disk, altered signal intensity in contiguous bone marrow, bulging of the anulus fibrosus, herniation of the nucleus pulposus, and contrast enhancement after intravenous administration of gadolinium diethylenetriaminepentaacetic acid (DTPA)--resemble observations from human clinical studies. Classification of degenerating disks and identification of MR imaging characteristics of each type may improve the interpretation of MR images and recognition of early disk degeneration in humans.
由于犬椎间盘的结构、成熟过程和退变情况与人类相似，作者开发了一种犬急性椎间盘退变模型。对18只犬的椎间盘突出进行了磁共振（MR）成像检查，然后用冷冻切片机进行切片。根据在冷冻切片中的形态学表现，大多数腰椎间盘可分为六种类型之一。每种类型都有其特征性表现以及在MR图像上的独特外观。本研究的结果——包括椎间盘信号强度降低、相邻骨髓信号强度改变、纤维环膨出、髓核突出以及静脉注射钆二乙烯三胺五乙酸（DTPA）后的对比增强——与人类临床研究的观察结果相似。退变椎间盘的分类以及每种类型MR成像特征的识别可能会改善对MR图像的解读，并有助于识别人类早期椎间盘退变。
