Hopper K D, Moser R P, Haseman D B, Sweet D E, Madewell J E, Kransdorf M J
Department of Radiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Radiology. 1990 Apr;175(1):233-9. doi: 10.1148/radiology.175.1.2315487.
A review of the 690 cases of osteosarcoma in the radiographic file of the Armed Forces Institute of Pathology revealed 29 cases of "osteosarcomatosis" (multiple skeletal sites of osteosarcoma). Fifteen of these patients were 18 years old and under and manifested rapidly appearing, usually symmetric, sclerotic metaphyseal lesions. The remaining 14 patients were more than 18 years old and had fewer, asymmetric sclerotic lesions. In most patients (28 of 29), a radiographically dominant skeletal tumor was seen. Pulmonary metastases occurred in the majority of patients and were detected at the same time as the bone lesions. These 29 patients were studied with regard to demographic data and skeletal distribution and radiographic appearance of their lesions. As a result of the findings, a metastatic origin from a primary dominant osteosarcoma is favored over a multifocal origin as the basis for osteosarcomatosis. Osteosarcomatosis is more commonly encountered in the mature skeleton than has been previously recognized.
对武装部队病理研究所X线档案中的690例骨肉瘤病例进行回顾，发现29例“骨肉瘤病”（骨肉瘤累及多个骨骼部位）。其中15例患者年龄在18岁及以下，表现为迅速出现的、通常对称的干骺端硬化性病变。其余14例患者年龄超过18岁，硬化性病变较少且不对称。在大多数患者（29例中的28例）中，可见一个在X线片上占主导地位的骨骼肿瘤。大多数患者发生肺转移，且与骨病变同时被发现。对这29例患者的人口统计学数据、骨骼分布以及病变的X线表现进行了研究。根据研究结果，骨肉瘤病的发病基础更倾向于原发性主导骨肉瘤的转移起源而非多灶起源。骨肉瘤病在成熟骨骼中比之前认为的更常见。
