Division of Surgical Oncology and Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Anticancer Res. 2012 Nov;32(11):4931-8.
The efficacy of adjuvant photodynamic therapy (PDT) using the new photosensitizer, talaporfin sodium (TPS), was assessed in 7 patients with bile duct carcinoma (BDC). The 664-nm semiconductor laser (100 J/cm(2)) was applied through endoscopy to the tumor lesion within 6 h after injection of TPS. Cases included three non-resectable and 4 resected BDC with remnant cancer cells at the bile duct stump. Radiated lesions exhibited mild inflammatory responses. Locally advanced tumor occluding bile duct was relieved by PDT and patency was maintained for 16 months. Two patients developed mild photodermatitis but no severe morbidity. One patient died of other disease, and two patients died of liver metastasis within 6 months, but local recurrence was not observed. Three patients maintained cancer-free survival for 6-13 months. One patient survived with good status for 24 months. Adjuvant TPS-PDT is a safe and useful treatment for local control of BDC. Compared to the conventional PDT, the patient's quality of life is remarkably improved.
采用新型光敏剂替拉泊芬钠（talaporfin sodium，TPS）的辅助光动力疗法（photodynamic therapy，PDT）在 7 例胆管癌（bile duct carcinoma，BDC）患者中的疗效进行了评估。664nm 半导体激光（100J/cm(2)）在 TPS 注射后 6 小时内通过内镜应用于肿瘤病变。病例包括 3 例不可切除和 4 例在胆管残端有残留癌细胞的切除 BDC。照射病变表现出轻度炎症反应。PDT 缓解了局部进展性胆管肿瘤阻塞，并保持通畅达 16 个月。2 例患者出现轻度光皮炎，但无严重发病。1 例患者死于其他疾病，2 例患者在 6 个月内死于肝转移，但未观察到局部复发。3 例患者癌症无进展生存 6-13 个月。1 例患者在 24 个月时生存状况良好。替拉泊芬钠辅助 PDT 是局部控制 BDC 的一种安全有效的治疗方法。与传统 PDT 相比，患者的生活质量显著提高。
