Brunetti P, Santeusanio F, Puxeddu A, Massi-Benedetti M, Calabrese G, Angeletti G, Bueti A, Scionti L, De Angelis M
Horm Metab Res Suppl. 1979(8):173-7.
With the aid of an artificial beta-cell (Biostator, Miles Laboratories Inc.), a different metabolic and biological pattern of behaviour was observed in benign versus malignant insulinoma. In the patient with beta-cell adenoma but not in the one with carcinoma, plasma insulin concentrations decreased promptly and markedly, and blood glucose increased during diazoxide and somatostatin infusion. Moreover, only in the adenoma patient was glucose need characterized by a circadian rhythm with the maximum values during daytime. This behavior could reflect the degree of tumor beta-cell differentiation. The controlled glucose and insulin infusion was of great help during and after surgical treatment.
借助人工β细胞（生物人工胰腺，迈尔斯实验室公司），在良性与恶性胰岛素瘤中观察到了不同的代谢和生物学行为模式。在患有β细胞腺瘤的患者中，而非患有癌的患者中，在输注二氮嗪和生长抑素期间，血浆胰岛素浓度迅速且显著下降，血糖升高。此外，只有腺瘤患者的葡萄糖需求呈现昼夜节律，白天达到最大值。这种行为可能反映了肿瘤β细胞的分化程度。在手术治疗期间及之后，控制葡萄糖和胰岛素输注非常有帮助。
