Cai Yanchen, Zhang Jian
Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Jul;26(14):629-32.
To investigate the expression of Fascin in sinonasal inverted papilloma (SNIP) and the relationship between Fascin expression and microvessel density (MVD).
The expression of Fascin and CD34 were determined by immunohistochemistry in 30 cases of SNIP, 12 cases of nasal squamous cell carcinoma (NSCC) and 10 cases of normal inferior turbinate (IT) tissues. Meanwhile, CD34, measure of MVD, was counted at the same time.
Fascin was expressed in 17 of 30 (56.6%) cases of SNIP, 10 of 12 (83.3%) cases of NSCC and 2 of 10 (20.0%) cases of normal IT tissues. Expression of Fascin was significantly increased in SNIP and NSCC compared to normal tissues (P < 0.01). MVD counts was 23.64 +/- 2.74, 45.10 +/- 5.45, 74.76 +/- 7.32, respectively (P < 0.01). There was a positive correlation between the expression of Fascin and MVD counts.
The high expression of Fascin and angiogenesis are significantly associated with biological behaviour of SNIP. Fascin may play an important role in the pathogenesis of SNIP and NSCC and synergic role with angiogenesis in progression of SNIP.
探讨Fascin在鼻腔鼻窦内翻性乳头状瘤（SNIP）中的表达及其与微血管密度（MVD）的关系。
采用免疫组织化学法检测30例SNIP、12例鼻腔鳞状细胞癌（NSCC）和10例正常下鼻甲（IT）组织中Fascin和CD34的表达，同时计数CD34（MVD的指标）。
Fascin在30例SNIP中的17例（56.6%）、12例NSCC中的10例（83.3%）及10例正常IT组织中的2例（20.0%）表达。与正常组织相比，Fascin在SNIP和NSCC中的表达显著增加（P<0.01）。MVD计数分别为23.64±2.74、45.10±5.45、74.76±7.32（P<0.01）。Fascin表达与MVD计数呈正相关。
Fascin的高表达和血管生成与SNIP的生物学行为显著相关。Fascin可能在SNIP和NSCC的发病机制中起重要作用，并在SNIP进展中与血管生成起协同作用。
